中药治疗糖尿病视网膜病变的疗效及机制研究进展
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篇名: | 中药治疗糖尿病视网膜病变的疗效及机制研究进展 |
TITLE: | Research progress on the curative effect and mechanism of traditional Chinese medicine in the treatment of diabetic retinopathy |
摘要: | 糖尿病视网膜病变(DR)是一种以微血管病变为主要特征的糖尿病并发症,严重的微血管损伤还可导致失明。传统药物治疗和手术治疗都存在一定的局限性。文献综述表明,DR的主要发病机制与氧化应激引起的炎症反应、细胞凋亡,以及生长因子、激素等的变化有关,中药单体(绿原酸)、单药(三七、蒲黄、葛根、枸杞等)、组方(补阳还五汤合六君子汤加减、血府逐瘀汤加减、四妙勇安汤等)以及中成药(川芎嗪注射液、复荣通脉胶囊、杞菊地黄丸等)都可以为DR的治疗提供有益的补充,其作用机制主要涉及抗氧化、抗炎、抗细胞凋亡、降低血管内皮生长因子表达、改善激素水平等。 |
ABSTRACT: | Diabetic retinopathy (DR) is one of the most important microvascular complications of diabetes mellitus, which can lead to blindness in severe cases. Both traditional drug therapy and surgical treatment have certain limitations. Literature review indicates that the main pathogenesis of DR is related to inflammation and apoptosis induced by oxidative stress, and changes in growth factors, hormones, etc. Monomer of traditional Chinese medicine (chlorogenic acid), single medicine (Panax notoginseng, Typha angustifolia, Pueraria montana root, Matrimony vine, etc.), prescription (modified Buyang huanwu decoction and Liujunzi decoction, modified Xuefu zhuyu decoction, Simiaoyong’an decoction, etc.) and Chinese patent medicine (Ligustrazine injection, Furong tongmai capsule, Qiju dihuang pill, etc.) can provide beneficial supplement for the treatment of DR. Its mechanism of action mainly involves antioxidant, anti-inflammatory, anti-apoptosis, decreasing the expression of vascular endothelial growth factor, improving hormone levels and so on. |
期刊: | 2023年第34卷第12期 |
作者: | 桑智慧;李慧红;周丽娟 |
AUTHORS: | SANG Zhihui,LI Huihong,ZHOU Lijuan |
关键字: | 糖尿病视网膜病变;中药;炎症;氧化应激;作用机制 |
KEYWORDS: | diabetic retinopathy; traditional Chinese medicine; inflammation; oxidative stress; mechanism of action |
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