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中药通过miRNA调控血管内皮细胞损伤防治动脉粥样硬化的作用机制研究进展
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| 篇名： | 中药通过miRNA调控血管内皮细胞损伤防治动脉粥样硬化的作用机制研究进展 |
| TITLE： | Research progress of the mechanism of traditional Chinese medicine in the prevention and treatment of athero-sclerosis based on miRNA regulation of vascular endothelial cell injury |
| 摘要： | 血管内皮细胞的损伤既是促进动脉粥样硬化（AS）初期斑块发生的始动条件，也是AS致病因素的重要环节。微RNA（miRNA）作为细胞间通信的重要媒介和基因调控因子，可以影响血管内皮功能，参与AS的发展进程。miRNA多靶点干预血管内皮细胞损伤的分子机制，目前已成为研究心血管病变的前沿热点。人参皂苷Rb2和丹皮酚等中药单体以及化痰祛瘀中药方可靶向调控miRNA改善内皮细胞炎症反应；黄芪甲苷、二氢杨梅素和三七皂苷可靶向调控miRNA抑制血管内皮氧化应激；丹红注射液、健脾祛痰化瘀方和丹皮酚可通过miRNA影响内皮细胞自噬；白藜芦醇、补肾活血方和补肾通脉方可作用于miRNA来抑制血管内皮衰老；石斛碱在调节miRNA改善内皮细胞内质网应激中发挥积极功效等。未来还需要对中药靶向调控miRNA治疗AS的效果、作用机制、诊疗方案和安全性进行更深入的研究。 |
| ABSTRACT： | The injury of vascular endothelial cells is not only the initial condition to promote the occurrence of early atherosclerosis （AS） plaques， but also an important link in the pathogenesis of AS. The microRNA （miRNA）， as an important medium of intercellular communication and gene regulatory factor， can affect vascular endothelial function and participate in the development of AS. The molecular mechanism of miRNA’s multi-target intervention in vascular endothelial cell injury has become a hot topic in the research of cardiovascular diseases. Monomers of traditional Chinese medicines such as ginsenoside Rb2 and paeonol， as well as traditional Chinese medicine for resolving phlegm and removing blood stasis could regulate miRNA to improve endothelial cell inflammation； astragaloside Ⅳ， dihydromyricetin and notoginsenoside could target miRNA and inhibit vascular endothelial oxidative stress； Danhong injection， Jianpi qutan and huayu prescription and paeonol could affect endothelial autophagy through miRNA； resveratrol， Bushen huoxue formula and Bushen tongmai formula could inhibit vascular endothelial aging by miRNA； dendrobine played an active role in regulating miRNA and improving endoplasmic reticulum stress. In the future， more in- depth research is needed on the effectiveness， mechanism of action， diagnosis and treatment plans， and safety of targeted regulation of miRNA for AS therapy by traditional Chinese medicine. |
| 期刊： | 2023年第34卷第12期 |
| 作者： | 刘丹丹；秦合伟；高洋；孙孟艳；王梦楠；牛雨晴；宋雪梅 |
| AUTHORS： | LIU Dandan，QIN Hewei，GAO Yang，SUN Mengyan，WANG Mengnan，NIU Yuqing，SONG Xuemei |
| 关键字： | 微RNA；内皮细胞损伤；动脉粥样硬化；中药；作用机制 |
| KEYWORDS： | microRNA； endothelial cell injury； atheroscle- |
| 阅读数： | 146 次 |
| 本月下载数： | 3 次 |
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