黄芪干预糖尿病视网膜病变的有效成分及其作用机制研究进展
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篇名: 黄芪干预糖尿病视网膜病变的有效成分及其作用机制研究进展
TITLE: Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism
摘要: 糖尿病视网膜病变是糖尿病的一种常见并发症,对人类视力健康产生了很大威胁。近几年研究表明,黄芪中皂苷类、多糖类、黄酮类成分通过作用于核因子κB、缺氧诱导因子1α、神经胶质纤维酸性蛋白、谷氨酰胺合成酶、醛糖还原酶和多种微小核糖核酸等相关靶点,调节磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白、沉默信息调节因子1/核因子E2相关因子2、B细胞淋巴瘤2等信号通路,从而发挥抗炎、抗微血管病变、抗神经退行性病变、抗细胞凋亡的作用,进而达到治疗糖尿病视网膜病变的目的。
ABSTRACT: Diabetic retinopathy (DR) is a common complication of diabetes, which causes a great threat to the health of human vision. Recent studies have shown that saponins, polysaccharides and flavonoids in Astragali Radix regulate phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway, silent information regulator 1/nuclear factor erythroid 2-related factor 2 pathway, B-cell lymphoma-2 and other signaling pathways by acting on nuclear factor-κB, hypoxia-inducible factor-1α, glial fibrillary acidic protein, glutamine synthetase, aldose reductase, multiple miRNA and other related targets, so as to exert anti- inflammatory, anti-microangiopathy, anti-neurodegenerative disease and anti-apoptosis, and then achieve the purpose of treating DR.
期刊: 2023年第34卷第11期
作者: 刘芮诚;孔玲;孙野;王喜军
AUTHORS: LIU Ruicheng,KONG Ling,SUN Ye,WANG Xijun
关键字: 糖尿病视网膜病变;黄芪;有效成分;作用机制
KEYWORDS: diabetic retinopathy; Astragali Radix; active component; mechanisms
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