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基因检测在降脂药物个体化治疗中的应用
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| 篇名： | 基因检测在降脂药物个体化治疗中的应用 |
| TITLE： | Application of gene detection in individualized treatment of lipid-lowering drugs |
| 摘要： | 血脂异常在临床上主要表现为高脂血症，是导致动脉粥样硬化、冠心病和脑卒中等心脑血管疾病发生的重要危险因素。临床上主要采用降脂药物进行治疗，但存在个体差异、基因影响等问题。因此，有必要对患者进行基因检测，从而指导降脂药物的个体化应用。本文主要对基因检测的定义和降脂药物的个体化治疗进行了概述，并介绍了基因检测在降脂药物（他汀类、贝特类、烟酸和依折麦布）个体化治疗方面的应用。其中APOE、SLCO1B1和CYP450家族的基因多态性对他汀类药物的疗效和安全性起到关键作用，APOA/B/C家族基因多态性对非诺贝特的疗效有显著影响，HCAR2和DGAT2基因多态性对烟酸的疗效具有重要影响，NPC1L1基因多态性对依折麦布的疗效影响较大。建议对血脂异常的患者进行基因检测，以选择合适的治疗策略，从而进行个体化用药指导。 |
| ABSTRACT： | The main clinical manifestation of dyslipidemia is hyperlipidemia， which is an important risk factor leading to the occurrence of cardiovascular and cerebrovascular diseases such as atherosclerosis， coronary heart disease and stroke. In clinical practice， lipid-lowering drugs are mainly used for treatment， but there are issues such as individual differences and genetic effects. Therefore， it is necessary to perform gene detection on patients， so as to guide individualized application of lipid-lowering drugs. This review mainly previews the definition of gene detection and the individualized treatment of lipid-lowering drugs， and introduces the application of gene detection in the individualized treatment of lipid-lowering drugs （statins， fibrates， nicotinic acid and ezetimibe）. Among them， the gene polymorphisms of APOE， SLCO1B1 and CYP450 family play a key role in the efficacy and safety of statins； the gene polymorphisms of APOA/B/C family have a significant impact on the efficacy of fenofibrate； the gene polymorphisms of HCAR2 and DGAT2 have an important impact on the efficacy of niacin； the gene polymorphisms of NPC1L1 have a significant impact on the efficacy of ezetimibe. It is suggested to conduct genotype detection for patients with dyslipidemia to select appropriate treatment strategies， so as to provide individualized medication guidance. |
| 期刊： | 2023年第34卷第09期 |
| 作者： | 朱扬媚；曹建刚；周玉生 |
| AUTHORS： | ZHU Yangmei，CAO Jiangang，ZHOU Yusheng |
| 关键字： | 基因检测；降脂药物；个体化治疗；基因多态性 |
| KEYWORDS： | gene detection； lipid-lowering drugs； individualized treatment； gene polymorphism |
| 阅读数： | 217 次 |
| 本月下载数： | 17 次 |
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