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固肾安胎丸联合达肝素钠治疗ACA阳性复发性流产的临床观察
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| 篇名： | 固肾安胎丸联合达肝素钠治疗ACA阳性复发性流产的临床观察 |
| TITLE： | Clinical observation of Gushen antai pill combined with heparin sodium in the treatment of anticardiolipin antibody-positive recurrent abortion |
| 摘要： | 目的 探讨固肾安胎丸联合达肝素钠对抗心磷脂抗体（ACA）阳性复发性流产患者的临床疗效。方法将ACA阳性复发性流产患者203例随机分为对照组（n＝101）和联合治疗组（n＝102）。对照组患者在基础治疗的基础上采用达肝素钠治疗，联合治疗组患者在对照组治疗的基础上加用固肾安胎丸治疗。收集患者血清样本，采用酶联免疫吸附试验法检测2组患者血清白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、环氧化酶2（COX-2）、β人绒毛膜促性腺激素（β-HCG）、ACA水平并计算抗体转阴率，观察患者的临床疗效，同时记录不良反应发生情况。结果治疗后，联合治疗组患者的妊娠成功率和抗体转阴率均显著高于对照组（P＜0.05），流产率显著低于对照组（P＜0.05）；2组患者血清IL-6、TNF-α、ACA水平均较治疗前显著下降（P＜0.05），COX-2、β-HCG水平均较治疗前显著升高（P＜0.05），且联合治疗组患者上述指标水平变化更显著（P＜0.05）。2组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论固肾安胎丸可通过上调ACA阳性复发性流产患者血清COX-2水平、下调IL-6水平来维持β-HCG的高表达，降低ACA水平，改善免疫微环境，从而提高妊娠成功率。 |
| ABSTRACT： | OBJECTIVE To investigate the clinical efficacy of Gushen antai pills combined with heparin sodium in the treatment of antiphospholipin antibody （ACA）-positive recurrent abortion. METHODS A total of 203 ACA-positive recurrent abortion patients were randomly divided into control group （n＝101） and combination treatment group （n＝102）. Control group was additionally treated with heparin sodium on basis of basic treatment， and combination treatment group was additionally treated with Gushen antai pills on the basis of control group. Serum samples were collected from patients， the levels of interleukin 6 （IL- 6）， tumor necrosis factor α （TNF-α）， cyclooxygenase 2 （COX-2）， β-human chorionic gonadotropin （β-HCG） and ACA were detected by enzyme-linked immunosorbent assay. The antibody-negative conversion rate was calculated， the clinical efficacy of the patient was observed， and the occurrence of adverse drug reactions was recorded. RESULTS After treatment， the pregnancy success rate and antibody-negative conversion rate of combination treatment group were significantly higher than those in the control group （P＜0.05）， and the abortion rate was significantly lower than that in the control group （P＜0.05）. Compared with before treatment， serum levels of IL-6， TNF-α and ACA in 2 groups were decreased significantly （P＜0.05）， while the levels of COX-2 and β-HCG were increased significantly （P＜0.05）； the changes of above indexes in combination treatment group were more significant（P＜0.05）. There was no statistical significance in the incidence of adverse drug reactions between 2 groups（P＞0.05）. CONCLUSIONS Gushen antai pills can maintain high expression of β-HCG， reduce the level of ACA and improve immune microenvironment in patients with ACA-positive recurrent abortion by increasing the serum level of COX-2 and decreasing the serum level of IL-6， so as to increase the success rate of pregnancy. |
| 期刊： | 2023年第34卷第07期 |
| 作者： | 张丽；董冰莹；袁小丽 |
| AUTHORS： | ZHANG Li，DONG Bingying，YUAN Xiaoli |
| 关键字： | 复发性流产：固肾安胎丸；达肝素钠；抗心磷脂抗体；临床疗效 |
| KEYWORDS： | recurrent abortion； Gushen antai pill； heparin sodium； anticardiolipin antibody； clinical efficacy |
| 阅读数： | 188 次 |
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