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参芪调肾方的化学成分分析
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| 篇名： | 参芪调肾方的化学成分分析 |
| TITLE： | Analysis of chemical components of Shenqi tiaoshen formula |
| 摘要： | 目的 分析参芪调肾方（SQTS）的化学成分。方法基于超高效液相色谱-四极杆/静电场轨道阱高分辨质谱技术，以ACQUITYUPLCBEHC18为色谱柱，0.1%甲酸溶液-0.1%甲酸乙腈溶液为流动相（梯度洗脱），流速为0.4mL/min，柱温为40℃，进样量为5μL；采用电喷雾电离源进行正、负离子扫描，扫描范围为m/z100～1500。结合TCMSP、PubChem等数据库，建立SQTS活性成分数据库并结合相关文献进行成分鉴定。结果与结论从SQTS中共鉴定出131个化学成分，涉及萜类23个、黄酮类22个、苯丙素类21个、生物碱类12个、酚类11个、氨基酸衍生物9个、脂肪酰类4个、有机酸3个等，包括芦丁、川陈皮素、辛弗林、肉桂酸、人参皂苷Rg1等成分；主要成分的裂解过程涉及糖苷键断裂、脱水等。 |
| ABSTRACT： | OBJECTIVE To analyze chemical components of Shenqi tiaoshen formula （SQTS）. METHODS UPLC-QE-MS method was adopted. The determination was performed on ACQUITY UPLC BEH C18 column with mobile phase consisted of 0.1% formic acid solution-0.1% formic acid acetonitrile solution （gradient elution） at the flow rate of 0.4 mL/min. The column temperature was set at 40 ℃ ， and the sample size was 5 μL. The electrospray ionization source was used to scan positive and negative ions， and the scanning range was m/z 100-1 500. Combined with TCMSP， PubChem and other databases， SQTS active component database was established and the components were identified in combination with relevant literature. RESULTS & CONCLUSIONS Totally 131 chemical components were identified from SQTS， including 23 terpenoids， 22 flavonoids， 21 phenylpropanoids， 12 alkaloids， 11 phenols， 9 amino acid derivatives， 4 fatty acyls， 3 organic acids and others， such as rutin， citrinin， synephrine， cinnamic acid and ginsenoside Rg1，etc. The cracking process of the main components involved the breaking of glycosidic bonds， dehydration， etc. |
| 期刊： | 2023年第34卷第06期 |
| 作者： | 尹丹丹；杨勤军；李泽庚 |
| AUTHORS： | YIN Dandan，YANG Qinjun，LI Zegeng |
| 关键字： | 参芪调肾方；化学成分；超高效液相色谱-四极杆/静电场轨道阱高分辨质谱；结构鉴定 |
| KEYWORDS： | Shenqi tiaoshen formula； chemical components； UPLC-QE-MS； structure identification |
| 阅读数： | 143 次 |
| 本月下载数： | 3 次 |
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