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天麻不同提取部位抗缺血性脑卒中作用比较
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| 篇名： | 天麻不同提取部位抗缺血性脑卒中作用比较 |
| TITLE： | Comparison of anti-ischemic stroke effect of different extraction parts from Gastrodia elata |
| 摘要： | 目的 比较天麻不同提取部位的抗缺血性脑卒中（IS）作用，为筛选天麻抗IS的有效部位提供参考。方法采用乙醇回流提取、乙酸乙酯萃取法对天麻进行提取分离。以花生四烯酸颈内动脉注射诱导大鼠弥漫性脑血栓模型，以缺血侧脑组织中伊文思蓝（EB）含量为指标考察天麻生粉、天麻醇提取物、天麻醇提取残渣、天麻乙酸乙酯提取物、天麻乙酸乙酯提取残渣、天麻素以及阿司匹林（阳性对照药）的抗IS作用。结果与模型组比较，阿司匹林、天麻醇提取物、天麻乙酸乙酯提取物均可显著降低模型大鼠缺血侧脑组织中EB含量（P＜0.05）；天麻生粉有降低模型大鼠缺血侧脑组织中EB含量的趋势，但差异无统计学意义（P＞0.05）；天麻醇提取残渣、天麻乙酸乙酯提取残渣、天麻素对模型大鼠缺血侧脑组织中EB含量均几乎无影响。结论天麻醇提取物和天麻乙酸乙酯提取物均具有抗IS作用，且作用强于天麻生粉。 |
| ABSTRACT： | OBJECTIVE To compare anti-ischemic stroke （IS） effect of different extraction parts from Gastrodia elata， and to provide reference for screening the anti-IS effective parts of G. elata. METHODS G. elata was extracted and separated by ethanol reflux extraction and ethyl acetate extraction. The rat model of diffuse cerebral thrombosis was induced by internal carotid artery injection of arachidonic acid （AA）； the anti-IS effect of G. elata powder， ethanol extract of G. elata， residue of ethanol extract of G. elata， ethyl acetate extract of G. elata， residue of ethyl acetate extract of G. elata， gastrodin and aspirin （positive control drug） were investigated with the content of Evans blue （EB） in the ischemic brain tissue as index. RESULTS Compared with model group， aspirin， ethanol extract of G. elata and ethyl acetate extract of G. elata could significantly decrease the content of EB in the ischemic brain tissue of model rats （P＜0.05）. G. elata powder had the tendency to reduce the content of EB in the ischemic brain tissue of model rats， without statistical significance （P＞0.05）. The residue of ethanol extract of G. elata， residue of ethyl acetate extract of G. elata and gastrodin had little effect on the content of EB in the ischemic brain tissue of model rats. CONCLUSIONS Both ethanol extract of G. elata and ethyl acetate extract of G. elata have anti-IS effects， which are stronger than that of G. elata powder. |
| 期刊： | 2023年第34卷第04期 |
| 作者： | 许春萍；杨茜；孟庆婷；颜明丽；宁珑；孙航；何芳雁 |
| AUTHORS： | XU Chunping，YANG Qian，MENG Qingting，YAN Mingli，NING Long，SUN Hang，HE Fangyan |
| 关键字： | 天麻；缺血性脑卒中；提取部位；药效学；有效部位 |
| KEYWORDS： | Gastrodia elata； ischemic stroke； extraction part； pharmacodynamics； effective part |
| 阅读数： | 174 次 |
| 本月下载数： | 2 次 |
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