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青蒿素及其衍生物防治心血管疾病的研究进展
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| 篇名： | 青蒿素及其衍生物防治心血管疾病的研究进展 |
| TITLE： | Research progress of artemisinin and its derivatives in prevention and treatment of cardiovascular diseases |
| 摘要： | 青蒿素是从植物青蒿中分离出来的含过氧基团的倍半萜内酯，具有抗疟疾活性，是治疗疟疾的有效药物。随着人们对青蒿素研究的逐步深入，青蒿素及其衍生物在其他系统的药理作用也逐渐成为研究的热点。本文对青蒿素及其衍生物防治心血管疾病的研究进展进行了综述。青蒿素及其衍生物在心血管疾病的防治中显示出了抗动脉粥样硬化、降血脂、抑制血管重塑、降压、改善心室重构、抗心律失常、保护血管内皮、防治糖尿病心血管并发症及保护心肌细胞等药理作用，为高血压、心律失常、冠心病支架置入术后并发症、高脂血症等心内科常见疾病提供了新的治疗策略。但关于青蒿素及其衍生物的抗血小板聚集作用、抗血栓的研究较少，很多药理作用背后的分子机制尚未明确，且临床应用不多，仍然需要大量的基础研究和临床试验来解答这些问题。 |
| ABSTRACT： | Artemisinin is a sesquiterpene lactone containing a peroxide group isolated from the plant Artemisia annua. It has antimalarial activity and is effective for the treatment of malaria. With the deepening of research on artemisinin， the pharmacological effects of artemisinin and its derivatives in other systems have gradually become a research hotspot. This article reviews the research progress of artemisinin and its derivatives in the prevention and treatment of cardiovascular diseases. Artemisinin and its derivatives in the prevention and treatment of cardiovascular disease have shown anti-atherosclerosis， lipid- lowering， inhibition of vascular remodeling， reducing vascular pressure， improving ventricular remodeling， anti-arrhythmia， protection of vascular endothelium， prevention and treatment of diabetic cardiovascular complications and protection of myocardial cells and other pharmacological effects. It provides a new treatment strategy for common cardiovascular diseases such as hypertension， arrhythmia， coronary heart disease complications after stent implantation， hyperlipidemia， etc. However， there are few studies on the antiplatelet aggregation and antithrombotic effects of artemisinin and its derivatives， the molecular mechanisms behind many pharmacological effects have not yet been clarified， and there is little clinical application. A large number of basic studies and clinical trials are still needed to answer these questions. |
| 期刊： | 2023年第34卷第02期 |
| 作者： | 罗文宽；卢健棋；陈文鹏；庞延；潘朝锌；温志浩 |
| AUTHORS： | LUO Wenkuan，LU Jianqi，CHEN Wenpeng，PANG Yan，PAN Chaoxin，WEN Zhihao |
| 关键字： | 青蒿素；衍生物；心血管疾病；药理作用 |
| KEYWORDS： | artemisinin； derivatives； cardiovascular disease； pharmacological effect |
| 阅读数： | 453 次 |
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