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基于AHP-TOPSIS法的阿托西班临床合理用药评价标准的建立与应用
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| 篇名： | 基于AHP-TOPSIS法的阿托西班临床合理用药评价标准的建立与应用 |
| TITLE： | Establishment and application of evaluation criteria for clinical rational drug use of atosiban based on AHP-TOPSIS method |
| 摘要： | 目的 建立阿托西班的临床合理用药评价标准，为临床合理使用阿托西班提供参考。方法以醋酸阿托西班注射液说明书、相关指南为依据，由合理用药评价小组制定合理用药评价标准，包括5个一级指标、8个二级指标。采用层次分析（AHP）法计算二级指标的权重系数，利用逼近理想值排序（TOPSIS）法对广州医科大学附属第三医院（以下简称“本院”）190例妊娠期妇女使用醋酸阿托西班注射液的情况进行回顾性评价，根据相对接近度将评价结果分为用药合理、用药基本合理、用药不合理3个层次。结果190例妊娠期妇女中，49例（25.8%）为阿托西班用药合理，39例（20.5%）为用药基本合理，102例（53.7%）为用药不合理；AHP-TOPSIS法所得评价结果与临床实际情况相符。用药不合理的主要问题为超适应证用药、用法用量不合理、超疗程用药及未进行适宜的经济性考量。结论通过AHP-TOPSIS法建立了阿托西班临床应用的合理性评价标准，该法所得评价结果可量化、科学可信。该药在本院的不合理使用现象较为普遍，临床应用时应加强管理。 |
| ABSTRACT： | OBJECTIVE To establish evaluation criteria for rational drug use of atosiban in clinic， and to provide reference for rational drug use of atosiban in clinic. METHODS Based on the drug instructions of atosiban acetate injection and related guidelines， the experts of the Evaluation Group of Rational Drug Use formulated the evaluation criteria of rational drug use， including 5 primary indexes and 8 secondary indexes. The weight coefficients of secondary indexes were calculated by analytic hierarchy process （AHP）， and the use of atosiban acetate injection in 190 pregnant women from the Third Affiliated Hospital of Guangzhou Medical University （referred to as “our hospital”） was evaluated retrospectively by technique for order preference by similarity to an ideal solution （TOPSIS）. The evaluation results were divided into three levels including reasonable， basic reasonable and unreasonable application based on the relative approach degree. RESULTS Among 190 pregnant women， 49 （25.8%） were treated with atosiban reasonably， 39 （20.5%） were treated with atosiban basic reasonably， and 102 （53.7%） were treated with atosiban unreasonably. The evaluation results obtained by AHP-TOPSIS method were consistent with the actual situation in clinic. The main problems of the unreasonably use were super indications， unreasonable usage and dosage， over the course of treatment and the lack of proper economic consideration. CONCLUSIONS The rationality evaluation criteria of atosiban’s clinical application are established by AHP-TOPSIS method； the evaluation results obtained by this method are quantifiable， scientific and reliable. The unreasonable use of atosiban is common in our hospital， and the management should be strengthened in clinical application. |
| 期刊： | 2023年第34卷第01期 |
| 作者： | 殷锦锦；杜培丽；谭湘萍；梅峥嵘；施胜英；刘少志 |
| AUTHORS： | YIN Jinjin，DU Peili，TAN Xiangping，MEI Zhengrong，SHI Shengying，LIU Shaozhi |
| 关键字： | 阿托西班；合理用药；评价标准；层次分析法；逼近理想值排序法 |
| KEYWORDS： | atosiban； rational drug use； evaluation criteria； |
| 阅读数： | 212 次 |
| 本月下载数： | 14 次 |
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