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国内抗菌药物临床应用分级管理目录与WHO抗菌药物AWaRe分级目录的对比分析
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| 篇名： | 国内抗菌药物临床应用分级管理目录与WHO抗菌药物AWaRe分级目录的对比分析 |
| TITLE： | Comparative analysis of domestic classification management list for clinical use of antibiotics versus WHO AWaRe classification list of antibiotics |
| 摘要： | 目的 为我国动态调整抗菌药物临床应用分级管理目录、促进其合理使用提供参考和建议。方法汇总各省份最新版抗菌药物临床应用分级管理目录作为“国家版目录”，与2021年WHO抗菌药物AWaRe分级目录（简称“AWaRe分级目录”）进行对比，描述性统计分析两目录中不同级别抗菌药物品种数及其差异。结果根据不同的分级原则，国家版目录将262种抗菌药物制剂分为非限制（84种）、限制（83种）和特殊使用级（95种），AWaRe分级目录将258种抗菌药物制剂分为可用（87种）、慎用（142种）和备用级（29种）；两目录共同收录的抗菌药物制剂有182种。在国家版目录中，非限制使用级抗菌药物制剂有36种为可用级，30种为慎用级，1种为备用级；限制使用级抗菌药物制剂有7种为可用级，46种为慎用级，3种为备用级；特殊使用级抗菌药物制剂有9种为可用级，35种为慎用级，15种为备用级；其中，91种抗菌药物制剂是WHO不推荐使用的（20种）或AWaRe分级目录未收录的（71种）。结论两目录的分级方法在分级原则以及部分药品的级别制定上不尽相同。抗菌药物临床应用分级管理目录是抗菌药物管理工作的抓手之一，未来需要开展更多的研究为优化我国抗菌药物分级管理提供充足证据。 |
| ABSTRACT： | OBJECTIVE To provide reference and suggestions for dynamic adjustment of classification management lists for clinical use of antibiotics and the promotion of rational use of antibiotics. METHODS The latest version of provincial classification management lists for clinical use of antibiotics were aggregated into the “national list”， which was compared with 2021 WHO AWaRe classification list of antibiotics （hereinafter referred as to “AWaRe classification list”） to make a descriptive statistical analysis about the number of different classes of antibiotics in the two lists and their differences. RESULTS Based on the different classification principles， 262 kinds of antibiotic preparations in the national list were classified into non-restricted （84）， restricted （83） and highly-restricted classes （95）， and 258 kinds in the AWaRe classification list were classified into access （87）， watch （142） and reserve classes （29）； 182 kinds of antibiotic preparations were both included in the two lists. In the national list， among the non-restricted antibiotic preparations， 36 kinds belonged to access class， 30 belonged to watch class and 1 belonged to reserve class； among restricted antibiotic preparations， 7 belonged to access class， 46 kinds belonged to watch class and 3 belonged to reserve class； among highly-restricted antibiotic 82805019。E-mail：yyy211anne@163.com preparations， 9 belonged to access class， 35 belonged to watch class and 15 kinds belonged to reserve class. Among them， 91 kinds of antibiotic preparations were not recommended by WHO （20 kinds） or not included in the AWaRe classification list （71 kinds）. CONCLUSIONS The classification methods of two lists are different in classification principles and grading of some similar drugs. The classification management list of antibiotics is one of the key points of antibiotics management， more research is needed in the future to provide sufficient evidence for optimizing antibiotics classification management. |
| 期刊： | 2022年第33卷第24期 |
| 作者： | 杨瑶瑶，凌可欣，张翕，杜可欣，张琬朦，胡琳，郑波，管晓东，海沙尔江⋅吾守尔，史录文 |
| AUTHORS： | YANG Yaoyao，LING Kexin，ZHANG Xi， DU Kexin，ZHANG Wanmeng，HU Lin，ZHENG Bo，GUAN Xiaodong，Haishaerjiang·Wushouer，SHI Luwen |
| 关键字： | 抗菌药物；分级管理；AWaRe分级目录；中国；世界卫生组织 |
| KEYWORDS： | antibiotics； classification management； AWaRe classification list； China； World Health Organization |
| 阅读数： | 276 次 |
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