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中药挥发油微乳凝胶剂的研究进展
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| 篇名： | 中药挥发油微乳凝胶剂的研究进展 |
| TITLE： | Research progress in volatile oil microemulsion gel of traditional Chinese medicine |
| 摘要： | 中药挥发油微乳凝胶剂具备微乳和凝胶的双重特点，可提高药物的溶解度和稳定性，促进药物吸收并达到长效缓释的效果，近年来在内科、妇科、儿科等临床疾病中的应用日趋广泛。本文通过检索相关文献，对中药挥发油微乳凝胶剂的特点、处方设计、成型工艺、质量评价进行综述。结果发现，中药挥发油微乳凝胶剂具有提高药物稳定性、增加药物经皮渗透、黏附性强、易洗除、制备方便等特点。处方设计由油相、表面活性剂、助表面活性剂、凝胶基质组成。成型工艺包含微乳的成型工艺和凝胶的成型工艺，其中微乳的形成主要利用伪三元相图法。质量评价分为中药挥发油和微乳凝胶两部分，挥发油的质量评价可从定性及定量两个方面进行研究，微乳凝胶需满足相关规定并进行体外释放和透皮吸收实验。 |
| ABSTRACT： | Volatile oil microemulsion gel of traditional Chinese medicine has the dual characteristics of microemulsion and gel， which can improve the solubility and stability of drugs， promote drug absorption and achieve long-term sustained release effect. In recent years， it has been widely used in clinical diseases such as internal medicine， gynecology and pediatrics. In this paper， the characteristics， prescription design， molding process and quality evaluation of volatile oil microemulsion gel of traditional Chinese medicine were reviewed by searching relevant literature. The results showed that the volatile oil microemulsion gel had the characteristics of improving the stability of the drug， increasing the transdermal penetration of the drug， strong adhesion， easy to wash， convenient preparation， etc. The prescription design consists of oil phase， surfactant， cosurfactant and gel matrix. The molding process includes the molding process of microemulsion and the molding process of gel， and the formation of microemulsion mainly uses the pseudo-ternary phase diagram method. The quality evaluation can be divided into 2 parts： volatile oil of traditional Chinese medicine and microemulsion gel. The quality evaluation of volatile oil can be studied qualitatively and quantitatively. Microemulsion gel should meet the relevant requirements and be tested for in vitro release and transdermal absorption. |
| 期刊： | 2022年第33卷第22期 |
| 作者： | 刘慧，殷佳，王静宜，刘超越，王信，李静蔚，傅春升 |
| AUTHORS： | LIU Hui，YIN Jia，WANG Jingyi，LIU Chaoyue，WANG Xin，LI Jingwei，FU Chunsheng |
| 关键字： | 中药挥发油；微乳凝胶；处方设计；成型工艺；质量评价 |
| KEYWORDS： | volatile oil of traditional Chinese medicine； |
| 阅读数： | 275 次 |
| 本月下载数： | 9 次 |
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