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复方黄芩浸膏粉干燥方式的优选
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| 篇名： | 复方黄芩浸膏粉干燥方式的优选 |
| TITLE： | Optimization of drying methods of Compound Scutellaria baicalensis extract powder |
| 摘要： | 目的优选复方黄芩浸膏粉的干燥方式。方法分别采用常压干燥、减压干燥和喷雾干燥方式制备复方黄芩浸膏粉，建立浸膏粉的高效液相色谱（HPLC）指纹图谱；以粒径、粒径分布、松密度等13个二级指标建立浸膏粉的物理指纹图谱；采用相似度评价法对比3种浸膏粉的HPLC指纹图谱和物理指纹图谱；通过二级指标转换计算均一性、堆积性、可压性、流动性和稳定性5个一级指标，评价3种浸膏粉的物理性质；并以二级指标计算3种浸膏粉的可压性参数——参数指数（IP）、参数轮廓指数（IPP）和良好可压性指数（IGC），评价粉体的压缩成型性。结果常压干燥、减压干燥和喷雾干燥所得复方黄芩浸膏粉的HPLC指纹图谱相似度均值分别为0.74、0.90和0.94，物理指纹图谱相似度均值分别为0.74、0.83和0.92，喷雾干燥浸膏粉整体相似度更高。物理指纹图谱研究结果表明，不同干燥方式所得浸膏粉物理性质有所差异，3种浸膏粉稳定性均较差，而堆积性均较好，喷雾干燥、减压干燥浸膏粉的均一性和可压性较常压干燥浸膏粉更优，但流动性较常压干燥浸膏粉差。压缩成型性分析结果表明，喷雾干燥浸膏粉的IP为0.54、IPP为5.23、IGC为5.03，可加少量的润滑剂后直接压片。结论不同干燥方式所得复方黄芩浸膏粉的HPLC指纹图谱与物理指纹图谱均存在差异。喷雾干燥浸膏粉整体质量更优，该方式更适用于复方黄芩浸膏的干燥。 |
| ABSTRACT： | OBJECTIVE To optimize the drying methods of Compound Scutellaria baicalensis extract powder. METHODS Compound S. baicalensis extract powder was prepared by atmospheric pressure drying， decompression drying and spray drying respectively， and high-performance liquid chromatography （HPLC） fingerprint of the extract powder was established. The physical fingerprint of the extract powder was established by 13 secondary indexes， such as particle size， particle size distribution and bulk density. HPLC fingerprints and physical fingerprints of 3 kinds of extract powders were compared by similarity evaluation method； through the conversion of the secondary indexes， five primary indexes of homogeneity， stacking， compressibility， fluidity and stability were calculated， and the physical properties of 3 kinds of extract powder were evaluated. The compressibility parameters of 3 kinds of extract powder such as index of parameter （IP）， index of parametric profile （IPP） and index of good compression （IGC） were calculated by the secondary index to evaluate the compression formability of the powder. RESULTS The similarity means of HPLC fingerprint of the extract powder obtained by atmospheric pressure drying， decompression drying and spray drying were 0.74， 0.90 and 0.94， respectively， and the similarity means of physical fingerprint were 0.74， 0.83 and 0.92， respectively. The overall similarity of spray drying extract powder was higher. The results of physical fingerprint analysis showed that the physical properties of the extract powder obtained by different drying methods were different. The 3 kinds of extract powder showed poor stability but good stacking. The homogenity and compressibility of extract powder by spray drying and decompression drying were better than those by atmospheric pressure drying， but the fluidity was worse than that by atmospheric pressure drying. The results of further compression formability analysis showed that the IP of spray drying extract powder was 0.54， IPP was 5.23， IGG was 5.03， and the spray drying extract powder could be directly pressed after adding a small amount of lubricant. CONCLUSIONS There are differences in HPLC and physical fingerprints of Compound S. baicalensis extract powder obtained by different drying methods. The spray drying extract powder possesses better Δ 基金项目 四川省公益性科研院所基本科研项目 （No.2022- 4-720） overall quality， which is more suitable for the drying of ＊第一作者副主任药师。研究方向：临床药学、药事管理、药物研 Compound S. baicalensis extract powder. 究。E-mail：hyptotti@163.com |
| 期刊： | 2022年第33卷第22期 |
| 作者： | 黄玉普，吴大章，汤玉梅，王森，王玉 |
| AUTHORS： | HUANG Yupu，WU Dazhang，TANG Yumei，WANG Sen，WANG Yu |
| 关键字： | 复方黄芩方；浸膏粉；高效液相色谱指纹图谱；物理指纹图谱；干燥方式；粉体学性质；成型性 |
| KEYWORDS： | Compound Scutellaria baicalensis prescription； |
| 阅读数： | 187 次 |
| 本月下载数： | 2 次 |
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