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中药防治心肌缺血再灌注损伤的文献计量学分析
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| 篇名： | 中药防治心肌缺血再灌注损伤的文献计量学分析 |
| TITLE： | Bibliometric analysis of traditional Chinese medicines for myocardial ischemia-reperfusion injury |
| 摘要： | 目的 对中药防治心肌缺血再灌注损伤（MIRI）领域的研究现状、热点进行分析，为开展相关研究提供参考依据。方法以WebofScience中收录的有关中医药治疗MIRI的文献为数据来源，进行文献计量学分析。结果本研究共计纳入972篇文献。近10年中药防治MIRI的研究呈现逐年上升趋势，2021年发表的文章被引次数最多；研究者多集中于中国；中国医学科学院北京协和医学院在该领域发文最多，并与其他机构有着较多的合作，在该领域有着较大的影响力；SunGuibo与SunXiaobo是该领域高产作者，但全球作者合作并不紧密，尚未形成一定规模的合作团队；MolecularMedicineReports可能是该领域最受欢迎的杂志。共被引分析发现，该领域的研究方向多集中在探索MIRI的发病机制以及找寻干预靶点方面；关键词分析显示，中药调控细胞凋亡、细胞焦亡、线粒体功能障碍、miRNA等途径改善MIRI的研究是该领域的热点，研究较多的信号通路有Nrf2通路、NF-κB通路、NLRP3炎症小体通路、TNF通路、SIRT3通路、JNK通路、PI3K/Akt通路、AMPK通路。结论近10年中药防治MIRI的研究备受关注，目前该领域的热点多集中于中药有效成分与中成药对MIRI的干预机制研究。此外，中药治疗MIRI的科研现阶段多集中于基础实验领域，建议未来多开展大规模、高质量、多中心、随机对照的临床研究，以期为中药应用于临床提供高级别循证医学证据。 |
| ABSTRACT： | OBJECTIVE To analyze the current status and research hot spots of traditional Chinese medicine （TCM）in the prevention and treatment of myocardial ischemia -reperfusion injury （MIRI），and to provide reference for developing relevant studies. METHODS A bibliometric analysis was performed with the literature on TCM treatments for MIRI included in the Web of Science as the data source . RESULTS A total of 972 literatures were included in this study . The research on TCM for prevention and treatment of MIRI in recent 10 years showed an increasing trend year by year ，and the literature published in 2021 were cited most frequently ；most research scholars focused in China ；Peking Union Medical College ，Chinese Academy of Medical Sciences had the most papers in this field ，and a lot of collaboration with other institutions ，which had a large influence in the field ；Sun Guibo and Sun Xiaobo were high -yielding authors in the field ，but the global authorship was not very close and had not formed cooperative teams of some scale ；Molecular Medicine Reports was perhaps the most popular journal in the field . Co-citation analysis found that the research direction in this field was mostly focused on exploring the pathogenesis of MIRI and finding intervention targets . Key words analysis revealed that TCM regulated apoptosis ， pyroptosis， mitochondrial dysfunction ， miRNA and other pathways to improve MIRI research was a hot spot in the field ，and more studies had focused on the Nrf 2 pathway，NF-κB pathway ，NLRP3 inflammasomepathway， TNF pathway ， SIRT3 pathway， JNK pathway ，PI3K/Akt pathway and AMPK pathway . CONCLUSIONS Much attention has been paid to the prevention and treatment of MIRI by TCM in the past 10 years，and the current hot spots in this field are mostly focused on the studies about the intervention mechanism of TCM ’s active ingredients and Chinese patent medicines on MIRI . Moreover，the research about TCM in the treatment of MIRI is mostly focused on the field of basic experiments at present ，and it is recommended that many large -scale，high-quality， multicenter，randomized controlled clinical studies should be carried out in the future ，to provide high -grade evidence -based evidence for the application of TCM in clinic . |
| 期刊： | 2022年第33卷第21期 |
| 作者： | 祁祥，卢健棋，王昱涵，武尚志，蒋志雄，朱智德，何晓羚 |
| AUTHORS： | QI Xiang，LU Jianqi，WANG Yuhan，WU Shangzhi，JIANG Zhixiong，ZHU Zhide，HE Xiaoling |
| 关键字： | 中药；心肌缺血再灌注损伤；心血管疾病；文献计量学 |
| KEYWORDS： | traditional Chinese medicine ；myocardial ischemia -reperfusion injury ；cardiovascular disease ；bibliometrics |
| 阅读数： | 148 次 |
| 本月下载数： | 9 次 |
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