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手术史对化疗所致恶心呕吐影响的病例对照研究
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| 篇名： | 手术史对化疗所致恶心呕吐影响的病例对照研究 |
| TITLE： | A case -control study of the effects of surgical history on chemotherapy -induced nausea and vomiting |
| 摘要： | 目的 探讨手术史对化疗所致恶心呕吐（CINV）的影响及相关因素。方法采用病例对照研究，以824例化疗患者为研究对象，统计患者的人口学资料、病史材料、化疗前检查数据、化疗情况共27项资料，使用Logistic回归模型分析手术史与CINV发生风险之间的关系，通过构建多个模型矫正潜在的混杂因素，并对有手术史的患者进行亚组分析。结果有手术史的患者CINV的发生率更高，未矫正的统计学结果为[OR＝1.72，95%CI（1.31，2.28），P＜0.001]，矫正潜在混杂因素后的统计学结果为[OR＝1.78，95%CI（1.28，2.48），P＝0.001]。亚组分析结果表明，手术距离化疗的时间（手-化时间）不同，手术史对CINV的影响也不同，差异有统计学意义（P＝0.027）。随着手-化时间的延长，CINV的发生风险呈下降趋势，差异有统计学意义（Pfortrend≤0.050）。相较于未做过手术的患者，1年以内做过手术的患者有较高的CINV发生风险[OR＝2.33，95%CI（1.52，3.59），P＜0.001]。结论有手术史的患者发生CINV的风险更高，该风险与手-化时间关系密切并随时间的延长呈现下降趋势。 |
| ABSTRACT： | OBJECTIVE To explore the influence of surgical history on chemotherapy -induced nausea and vomiting （CINV）. METHODS A retrospective case -control study was adopted ，with 824 patients undergoing chemotherapy as the object . A total of 27 items were collected ，including demographic data ，medical history data ，pre-chemotherapy data ，and chemotherapy treatment status. Logistic regression model was used to analyze the relationship between the history of surgery and the risk of CINV . The multiple models were constructed to correct potential confounding factors ，and subgroup analysis was performed on patients with surgical history . RESULTS The incidence of CINV was higher in patients with surgical history . The statistical result before adjustment was [OR＝1.72，95%CI（1.31，2.28），P＜0.001]；after adjusting potential confounding factors ，the statistical result was [OR＝1.78，95% CI（1.28，2.48），P＝0.001]. In the subgroup analysis ，the time between surgery and chemotherapy was different ， and the impact of surgical history on CINV was different ，and the results were statistically significant （P＝0.027）. The risk of CINV showed decreasing trend with the time ，and the results were statistically significant （P for trend ≤0.050）. Compared with patients who had not undergone surgery ，patients who had undergone surgery within one year had a higher risk of CINV [OR＝ 2.33，95%CI（1.52，3.59），P＜0.001]. CONCLUSIONS Patients with surgical history are more prone to CINV ，and the risk of CINV shows a downward trend in the length of time from surgery . |
| 期刊： | 2022年第33卷第19期 |
| 作者： | 孙博，张二锋，陈露，刘勋，李淑芳，马换青，潘丽丽，刘丹娜，王会品 |
| AUTHORS： | |
| 关键字： | 手术史；化疗所致恶心呕吐；危险因素；Logistic回归模型 |
| KEYWORDS： | surgical history ；chemotherapy-induced nausea and vomiting ；risk factors ；Logistic regression model |
| 阅读数： | 142 次 |
| 本月下载数： | 3 次 |
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