上海市金山区居家严重精神障碍患者用药依从性影响因素及药物不良反应调查分析-中国药房

上海市金山区居家严重精神障碍患者用药依从性影响因素及药物不良反应调查分析

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篇名：	上海市金山区居家严重精神障碍患者用药依从性影响因素及药物不良反应调查分析
TITLE：	Survey analysis of influential factors of medication compliance and adverse drug reactions of home -based patients with severe mental disorders in Jinshan district of Shanghai
摘要：	目的分析居家严重精神障碍患者用药依从性现状、影响因素及药物不良反应发生情况。方法整群抽取2022年1月上海市金山区纳入上海市精神卫生信息管理系统的居家严重精神障碍患者为研究对象，结合信息系统登记的相关基础数据并通过精神卫生条线医生面对面或电话开展问卷调查，了解患者的基本情况、用药依从性、精神症状、社会功能缺陷状况、药品使用信息和药物不良反应发生情况，并进行用药依从性的单因素和多因素Logistic回归分析。结果本次调查发放问卷2684份，回收有效问卷2606份，有效回收率为97.10%。居家严重精神障碍患者整体用药依从性为68.11%。多因素Logistic回归分析结果显示，51～60岁、未婚、离婚或丧偶、社会功能部分缺陷、社会功能无缺陷、使用第3代抗精神病药品是患者用药依从性的促进因素（P＜0.05）；费用类型为医保、不参与社会工作、住院总次数1～4次、住院总次数≥5次、精神症状一般、使用第2代抗精神病药品是患者用药依从性的阻碍因素（P＜0.05）。居家严重精神障碍患者药物不良反应发生率为10.59%，主要以第2代抗精神病药品为主，无新的、严重的不良反应上报。结论居家严重精神障碍患者的用药依从性受多种因素影响，亟需药师的参与，以促进患者用药的规范、合理。
ABSTRACT：	OBJECTIVE To analyze the status quo ，influential factors of medication compliance and adverse drug reactions of home-based patients with severe mental disorders . METHODS Patients with severe mental disorders at home who were enrolled in the Shanghai mental health information management system in Jinshan district of Shanghai in Jan . 2022 were selected as the research objects . In combination with the relevant basic data registered in the information system and through face -to-face or telephone surveys by mental health doctors ，basic information ，medication compliance ，mental symptoms ，social function defects ， drug use information and adverse drug reactions of patients were understood . Univariate and multivariate Logistic regression analysis of medication compliance were performed . RESULTS Totally 2 684 questionnaires were distributed and 2 606 valid questionnaires were recovered ，with an effective recovery rate of 97.10%. The overall medication compliance of patients with severe mental disorders at home was 68.11%. The results of multivariate Logistic regression analysis showed that 51-60 years old ，unmarried， divorced or widowed ，partial social function defects ，no social function defects ， and use of third -generation antipsychotic drugs were the promotion factors of medication compliance ，（P＜0.05）；medical insurance ，non participation in work ，total number of hospitalizations of 1-4 times，total number of hospitalizations ≥ 5 times，general mental symptoms ，and use of second -generation antipsychotic drugs were the obstacles to medication compliance （P＜0.05）. The incidence of adverse drug reactions in patients with severe mental disorders a t home was 10.59%，mainly caused by second -generation antipsychotic drugs，and no new and serious adverse reactions were reported . CONCLUSIONS The medication compliance of patients with severe mental disorders at home is affected by many factors . It is urgent to need pharmacists ’participation to promote the standardization and rationality of patients ’medication.
期刊：	2022年第33卷第19期
作者：	冒长青，聂莲莲，王勇，张宴萍，沈卫华，郭澄
AUTHORS：
关键字：	严重精神障碍；居家用药；用药依从性；药物不良反应；药学服务
KEYWORDS：	severe mental disorder ；home medication ；medication compliance ；adverse drug reactions ；pharmaceutical care
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