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蓝蓟滇紫草的质量标准研究
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| 篇名： | 蓝蓟滇紫草的质量标准研究 |
| TITLE： | Study on quality standard of Onosma echioides |
| 摘要： | 目的 制定蓝蓟滇紫草的质量标准。方法采集16批不同来源的蓝蓟滇紫草样品，对其进行外观性状观察、粉末显微鉴别和薄层色谱（TLC）鉴别，并对药材杂质、水分、总灰分、酸不溶性灰分进行检查。采用紫外-可见分光光度法测定药材中羟基萘醌总色素的含量；采用高效液相色谱法测定药材中左旋紫草素和β，β′-二甲基丙烯酰阿卡宁的含量。结果蓝蓟滇紫草药材及其粉末呈紫红色，显微可见非腺毛单细胞、栓化细胞、薄壁细胞和网纹导管等。TLC结果显示供试品色谱与对照品色谱相应位置上的斑点颜色及显色变化一致。暂定蓝蓟滇紫草药材水分、总灰分及酸不溶性成分分别不得过13.0%、18.0%、6.0%；羟基萘醌总色素含量不得少于0.80%，左旋紫草素含量不得少于0.06mg/g，β，β′-二甲基丙烯酰阿卡宁含量不得少于0.60mg/g。结论所建标准可为科学评价蓝蓟滇紫草药材的质量提供参考。 |
| ABSTRACT： | OBJECTIVE To establish the quality standard of Onosma echioides . METHODS Sixteen batches of O. echioides from different sources were collected to observe their appearance ，microscopic powder identification ，and TLC identification ；the impurity，moisture，total ash and acid -insoluble ash of the medicinal materials were examined . The total pigment content of hydroxynaphthoquinone in O. echioides was determined by UV -visible spectrophotometry ；the contents of alkannin and β，β′- dimethylacrylalkannin in O. echioides were determined by HPLC . RESULTS Medicinal material and powder of O. echioides were purplish red ；non-glandular single cells ，embolized cells ，parenchyma cells ，reticulate ducts could be seen microscopically . TLC results showed that the color and change of the spots in the chromatogram of test sample were consistent with that of the control . The contents of moisture ，total ash and acid insoluble ashshall not exceed 13.0%，18.0%，6.0%. The total pigment content of hydroxynaphthoquinone should not be less than 0.80%. The content of alkannin was recommended to be no less than 0.06 mg/g. The content of β，β′-dimethylacrylalkannin was recommended to be no less than 0.60 mg/g. CONCLUSIONS The established standard can provide reference for the scientific evaluation of the quality of the medicinal materials of O. echioides. |
| 期刊： | 2022年第33卷第19期 |
| 作者： | 王倩倩，庞克坚，高薇，张珂，陈韩英，张波 |
| AUTHORS： | |
| 关键字： | 蓝蓟滇紫草；质量标准；紫草；羟基萘醌总色素；左旋紫草素；β，β′-二甲基丙烯酰阿卡宁 |
| KEYWORDS： | Onosma echioides ；quality standard ；Arnebiae Radix ；hydroxynaphthoquinone；alkannin；β，β′-dimethylacry- |
| 阅读数： | 206 次 |
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