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基于循证医学证据和药物经济学模型的中成药临床综合评价
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| 篇名： | 基于循证医学证据和药物经济学模型的中成药临床综合评价 |
| TITLE： | Clinical comprehensive evaluation for Chinese patent medicine based on evidence-based medicine and pharma- coeconomic model |
| 摘要： | 目的 建立中成药临床综合评价方法，为临床合理用药提供参考。方法以全国合理用药监测网统计的2016－2020年山东省监测点医院中成药用药金额排名前10位的活血化瘀类中药注射剂为例，采用卫生技术评估结合客观评价法构建综合评价指标体系，基于循证医学证据和药物经济学模型对10种中药注射剂进行安全性、有效性与经济性的综合评价，并进行量化赋分。结果与结论10种中药注射剂的量化评估最终分值在26～37分之间；注射用红花黄色素在治疗脑梗死和冠心病心绞痛方面的综合得分最高，银杏二萜内酯葡胺注射液和舒血宁注射液在治疗冠心病方面的综合得分最高。由此可知，基于循证医学证据和药物经济学模型的中成药临床综合评价方法，可更加明确中成药的临床综合价值，促进临床合理用药，为下一步医保目录、基药目录调整和集采相关药物决策提供依据。 |
| ABSTRACT： | OBJECTIVE To conduct a c omprehensive clinical evaluation method of Chinese patent medicine ，and to provide reference for rational clinical drug use. METHODS Taking the top 10 Chinese patent medicine injections for promoting blood circulation and removing stasis in Shandong province from 2016 to 2020 collected by the National Rational Drug Use Monitoring Network as an example ，the method combining health technology assessment with objective judgement analysis is used to construct the comprehensive evaluation index system ；based on evidence-based medical evidence and pharmacoeconomic model ，the safety ， effectiveness and economy of the drug were evaluated comprehensively ，and the scores were quantified. RESULTS & CONCLUSIONS The final scores of the 10 kinds of Chinese patent medicine injections were between 26 and 37 scores. Safflower yellow for injection scored the highest score in the treatment of cerebral infarction and angina pectoris of coronary heart disease ， while Ginkgo diterpene lactone meglumine injection and Shuxuening injection had the highest scores in the treatment of coronary heart disease. The clinical comprehensive evaluation method of Chinese patent medicine based on evidence-based medical evidence and pharmacoeconomic model can clarify the comprehensive value of Chinese patent medicine in clinic ，promote rational drug use in clinic ，and provide basis for the next adjustment of medical insurance catalogue and essential medicine catalogue ，decision-making of centralized procurement of related drugs. |
| 期刊： | 2022年第33卷第15期 |
| 作者： | 唐显帅，郑磊，张明珠，管玉瑶，杨静 |
| AUTHORS： | TANG Xianshuai ，ZHENG Lei，ZHANG Mingzhu ，GUAN Yuyao ，YANG Jing |
| 关键字： | 药品临床综合评价；中成药；活血化瘀；安全性；有效性；药物经济学；循证医学 |
| KEYWORDS： | clinical comprehensive evaluation of drugs ；Chinese patent medicine ；promoting blood circulation and removing |
| 阅读数： | 236 次 |
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