中药治疗变应性接触性皮炎的药理作用机制
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篇名: 中药治疗变应性接触性皮炎的药理作用机制
TITLE: Pharmacological mechanism of traditional Chinese medicine in the treatment of allergic contact dermatitis
摘要: 变应性接触性皮炎(ACD)是一种常见的Ⅳ型过敏反应疾病,患病人群广,且严重影响患者的生活质量。为了解中药治疗ACD的药理作用机制,为临床应用及新药研发提供参考,本文对ACD的发病机制、可用于治疗ACD的中药及其作用机制进行综述。治疗ACD的中药主要是清热药(苦参、白鲜皮)、解表药(桂枝、苍耳子、防风)、祛风湿药(雷公藤、徐长卿)、利水渗湿药(车前子、地肤子)等,其作用机制主要包括抑制免疫球蛋白E分泌、调节辅助性T细胞1(Th1)与Th2细胞平衡、调节Th17与调节性T细胞平衡、降低肥大细胞脱颗粒比例以及抑制磷酸化细胞外信号调节激酶1/2/Toll样受体4/核因子κB(pERK1/2/TLR4/NF-κB)通路、黑色素瘤缺乏因子2/胱天蛋白酶1(AIM2/caspase-1)炎症小体信号通路、Wnt/β-连环蛋白(Wnt/β-catenin)通路、信号传导与转录激活因子3(STAT3)通路和促分裂原活化的蛋白激酶(MAPK)通路等。
ABSTRACT: Allergic contact dermatitis (ACD)is a common type Ⅳ allergic disease ,which has a wide range of patients ,and seriously affects the quality of patients ’lives. To understand the pharmacological mechanism of traditional Chinese medicine (TCM)in the treatment of ACD ,and to provide reference for clinical application and new drug research and development ,the relevant research literatures were reviewed from aspects of pathogenesis of ACD ,traditional Chinese medicine that can be used to treat ACD and its mechanism of action. TCM for the treatment of ACD mainly include heat-clearing medicines (Sophora flavescens,Dictamnus dasycarpus ),exterior-releasing medicines (Cinnamomum cassia ,Xanthium sibiricum ,Saposhnikovia divaricata),antirheumatic medicines (Tripterygium wilfordii ,Cynanchum paniculatum ),and damp-draining medicines (Plantago asiatica,Kochia scoparia ),etc. The main mechanisms include inhibition of IgE secretion ,regulation of Th 1/Th2 cell and Th 17/ Treg balance ,reduction of mast cells degranulation ratio ,inhibition of pERK 1/2/TLR4/NF-κ B pathway,AIM2/caspase-1 inflammasome signaling pathway ,Wnt/β-catenin pathway ,STAT3 pathway and MAPK pathway.
期刊: 2022年第33卷第14期
作者: 王谊,任孟月
AUTHORS: WANG Yi ,REN Mengyue
关键字: 变应性接触性皮炎;中药;药理学;作用机制
KEYWORDS: allergic contact dermatitis ;traditional Chinese medicine ;pharmacology;mechanism
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