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胡椒碱的药理作用及机制研究进展
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| 篇名： | 胡椒碱的药理作用及机制研究进展 |
| TITLE： | Research progress of pharmacological action and mechanism of piperine |
| 摘要： | 胡椒碱是存在于胡椒科植物胡椒PipernigrumL.中的一类酰胺类生物碱成分，具有保护心血管系统、调节糖脂代谢、抗肿瘤、改善神经系统疾病、抗炎等药理作用。本文通过对胡椒碱近几年的药理作用及机制的相关研究进行归纳总结发现，胡椒碱可通过减轻炎症反应和氧化应激水平，发挥保护心血管系统的作用；可通过抗炎、抗氧化作用改善线粒体功能，进而调控糖脂代谢；可通过介导Wnt/β-catenin、NF-κB/Nrf-2/KeAP-1/HO-1、PI3K/Akt、TGF-β1/Smad2/ERK1/2等信号通路，发挥抗肿瘤作用；可通过抑制自噬效应、减轻炎症反应、提高抗氧化能力、抑制神经元细胞凋亡、调控神经元中相关蛋白的表达，发挥改善神经系统疾病的作用；还能通过抑制NF-κB等信号通路活性，降低炎症相关蛋白的表达，发挥抗炎作用。但胡椒碱的作用机制并不完善，多数研究均停留在药效层面或某个信号通路及某个靶点上，不能从整体角度阐明其发挥药理作用的相关信号通路与具体作用靶点之间的相互联系。后续可深入明确胡椒碱具体作用靶点并进行临床相关试验研究，为胡椒碱的临床应用提供支撑。 |
| ABSTRACT： | Piperine is a kind of amide alkaloids presenting in Piper nigrum L.，which has the pharmacological action such as protecting cardiovascular system ，regulating glucose and lipid metabolism ，anti-tumor，improving nervous system diseases ， anti-inflammation and so on. This paper summarized the pharmacological action and mechanisms of piperine in recent years and found that piperine ，as the main active ingredient of P. nigrum ，could protect the cardiovascular system by reducing inflammation and oxidative stress ；improve mitochondrial function through anti-inflammatory and antioxidant effects ，thereby regulate glucose and lipid metabolism ；play an anti-tumor role by mediating the signaling pathways of Wnt/β-catenin，NF-κB/Nrf-2/KeAP-1/HO-1， PI3K/Akt，TGF-β1/Smad2/ERK1/2；improve neurological diseases by inhibiting autophagy ，relieving inflammation ，improving antioxidant，inhibiting neuronal apoptosis and regulating the expression of related proteins in neurons ；play an anti-inflammatory effect by inhibiting the activity of NF-κB and other signaling pathways and reducing the expression of inflammation-related proteins. However，the mechanism of action of piperine is not perfect ，and most of the studies have been confined to the pharmacological level or a certain signaling pathway and a certain target ，without being able to elucidate the interconnection between the relevant signaling pathway and the specific target from a holistic perspective. In the follow-up ，the specific targets of piperine can be identified and clinical trials can be carried out to provide support for the clinical application of piperine. |
| 期刊： | 2022年第33卷第13期 |
| 作者： | 林思，秦慧真，邓玲玉，张淼，谢凤凤，李泽宇，朱华 |
| AUTHORS： | LIN Si，QIN Huizhen ，DENG Lingyu ，ZHANG Miao，XIE Fengfeng ，LI Zeyu，ZHU Hua |
| 关键字： | 胡椒碱；酰胺类生物碱；药理作用；心血管；抗肿瘤 |
| KEYWORDS： | piperine；amide alkaloids ；pharmacological action ；cardiovascular；anti-tumor |
| 阅读数： | 778 次 |
| 本月下载数： | 18 次 |
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