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药物快速卫生技术评估方法学研究——以抗肿瘤用药为例
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| 篇名： | 药物快速卫生技术评估方法学研究——以抗肿瘤用药为例 |
| TITLE： | Methodological study of rapid health technology assessment of drugs ：taking antitumor drugs as an example |
| 摘要： | 目的 建立适合中国国情的、基于证据整合与价值判断的药物快速卫生技术评估（rHTA）方法学。方法采用文献综述法对卫生技术评估（HTA）、多准则决策分析（MCDA）进行研究，以抗肿瘤用药为抓手，初步形成基于我国国情的rHTA方法；再通过专家咨询法对抗肿瘤药物rHTA方法进行论证；最后以治疗非小细胞肺癌的药物为例初步验证其可行性。结果所构建的rHTA方法结合了HTA和MCDA的理论与原则：应用HTA收集与整合文献证据和真实世界证据，同时运用MCDA由多个利益相关方从不同角度对可获取的药物信息进行价值测量，建立药物rHTA的操作流程、价值评估的维度和指标、评分系统，并经治疗非小细胞肺癌的药物实例验证该方法可行。结论建立了一套基于HTA与MCDA的药物rHTA方法学，能够实现数据的快速收集与证据的整合，在短时间内为决策者提供循证决策支持。 |
| ABSTRACT： | OBJECT IVE To develop a rapid health technology assessment （rHTA）methodology of drugs based on evidence integration and value judgment ，which is suitable for China ’s national conditions. METHODS The literature review was adopted to study health technology assessment （HTA）and multi-criteria decision analysis （MCDA），and then rHTA method based on China ’s condition was formulated preliminarily with anti-tumor drugs ；the method of rHTA was demonstrated by expert consultation ； finally，the feasibility of rHTA was preliminarily verified taking the drugs for the treatment of non-small cell lung cancer as an example. RESULTS Established rHTA method combined the theory and principles of HTA and MCDA ：HTA method was used to guide the collection and synthesis of literature and real-world evidence ，while MCDA made the value measurements of achievable evidences by various stakeholders from different views ；it established the working process ，evaluation dimensions ，evaluation indicators and scoring system of rHTA. The feasibility of this method was verified by the drug example of treating non-small cell lung cancer. CONCLUSIONS A set of drug-driven rHTA methodology guidance based on HTA and MCDA is established. It can quickly collect and integrate evidence ，and provide evidence support for decision makers in a short time. |
| 期刊： | 2022年第33卷第11期 |
| 作者： | 刘梦娜，吴斌，艾丹丹，许倩，李雪，陈金榆，郭武栋 |
| AUTHORS： | LIU Mengna ，WU Bin，AI Dandan ，XU Qian，LI Xue，CHEN Jinyu，GUO Wudong |
| 关键字： | 抗肿瘤用药；快速卫生技术评估；卫生技术评估；多准则决策分析 |
| KEYWORDS： | anti-tumor drug use ；rapid health technology assessment ；health technology assessment ；multi-criteria decision |
| 阅读数： | 434 次 |
| 本月下载数： | 23 次 |
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