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调整有限因变量混合模型在药物经济学健康效用量表映射中的运用
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| 篇名： | 调整有限因变量混合模型在药物经济学健康效用量表映射中的运用 |
| TITLE： | Application of adjusted limited dependent variable mixed model in the mapping of pharmacoeconomic health utility scale |
| 摘要： | 目的 介绍调整有限因变量混合模型（ALDVMM）及其在映射研究中的运用情况，为需要通过映射获取健康效用值的药物经济学评价提供参考。方法采用文献研究的方法，分别从ALDVMM的开发背景、模型原理、模型确定与检验、模型优势以及目前该模型在实证研究中的运用现状等方面进行介绍。结果与结论ALDVMM是国外学者针对欧洲五维健康量表（EQ-5D）在健康效用值1处截断不连续且存在多峰现象而开发的混合模型。相较于传统模型，ALDVMM可行且更具有优势，能更有效、灵活地捕捉EQ-5D的实际分布情况并处理好边界值问题，有助于更准确、有效地获取健康效用值并开展更高质量的药物经济学评价。 |
| ABSTRACT： | OBJ ECTIVE To introduce adjusted limited dependent variable mixed model （ALDVMM）and study its application in mapping research ，so as to provide reference for pharmacoeconomic evaluation that needs to obtain health utility value through mapping. METHODS Using the method of literature research ，ALDVMM was introduced from the aspects of development background，model principle ，model determination and test ，model advantages and the current application of the model in empirical research. RESULTS & CONCLUSIONS ALDVMM is a mixed model developed by foreign scholars for the truncation and multimodality phenomenon of EuroQoL group ’s 5D（EQ-5D）at the health utility value 1. Compared with the traditional model，ALDVMM is feasible and has more advantages ，and can more effectively and flexibly capture the actual distribution of EQ-5D and deal with the boundary value problem ，which is helpful to obtain the health utility value more accurately and efficiently and carry out high-quality pharmacoeconomic evaluation. |
| 期刊： | 2022年第33卷第07期 |
| 作者： | 万楚川，徐怀伏 |
| AUTHORS： | WAN Chuchuan ，XU Huaifu |
| 关键字： | 调整有限因变量混合模型；健康效用值；映射；欧洲五维健康量表；药物经济学 |
| KEYWORDS： | adjusted limited dependent variable mixed model ；health utility value ；mapping；EuroQoL group ’s 5D； |
| 阅读数： | 244 次 |
| 本月下载数： | 5 次 |
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