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青翘质量等级标准研究
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| 篇名： | 青翘质量等级标准研究 |
| TITLE： | Study on quality grade standard of premature Forsythia suspensa |
| 摘要： | 目的 研究青翘的质量等级标准。方法采集全国连翘主产区的138批青翘药材，按2020年版《中国药典》相关方法检测青翘药材中杂质、水分、醇溶性浸出物、挥发油、连翘苷、连翘酯苷A等质量指标的含量，并筛选合格样品。采用层次分析与主成分分析（AHP-PCA）混合加权法确定上述指标（杂质限量除外）的综合权重，并计算青翘合格样品的综合得分，再根据K-均值聚类分析结果提出青翘质量等级划分建议。结果与结论青翘中杂质、水分、醇溶性浸出物、挥发油、连翘苷、连翘酯苷A的含量范围分别0～7.80％、1.60％～8.18％、13.13％～61.60％、0.21％～3.47％、0.02％～2.15％、0.79％～14.04％，平均含量分别为1.24％、4.97％、34.88％、2.01％、0.42％、6.86％，138批青翘药材共有47批合格。建议青翘质量等级标准可划分为3级：一级青翘的挥发油含量≥2.40％，连翘苷含量≥0.59％，连翘酯苷A含量≥8.34％，醇溶性浸出物含量≥38.66％，水分含量≤4.99％；二级青翘上述指标含量分别≥2.26％、≥0.41％、≥7.47％、≥32.58％、≤5.33％；三级青翘上述指标含量分别≥2.15％、≥0.32％、≥4.60％、≥31.52％、≤7.23％。 |
| ABSTRACT： | OBJECTIVE To study the quality grade stand ard of the premature Forsythia suspensa . METHODS A total of 138 batches of premature F. suspensa were collected from the main producing areas of F. suspensa in China. According to 2020 edition of Chinese Pharmacopoeia ，the contents of impurities ，moisture，ethanol-soluble extract ，volatile oil ，forsythin and forsythoside A in the premature F. suspense were determined ，and the qualified samples were screened. AHP-PCA mixed weighting method was used to give comprehensive weight to the indicators （except for the limit of impurity ）. The comprehensive score of the samples was calculated. The suggestions on the quality grade division of premature F. suspensa were put forward according to cluster analysis of K-mean value. RESULTS & CONCLUSIONS The contents of impurities ，moisture，ethanol-soluble extract ，volatile oil ，forsythin and forsythoside A in the premature F. suspense were 0-7.80％，1.60％-8.18％，13.13％-61.60％，0.21％-3.47％，0.02％-2.15％ and 0.79％-14.04％，respectively；average contents of them were 1.24％，4.97％，34.88％，2.01％，0.42％，6.86％，respectively. Totally 47 batches of 138 batches were qualified in all indexes. It is suggested that the quality grade of the premature F. suspense can be divided into three grades ：in first grade of F. suspense ，the contents of volatile oil ，forsythin，forsythoside A ， ethanol-soluble extract and moisture were ≥2.40％，≥0.59％，≥8.34％，≥38.66％ and ≤4.99％，respectively；in second grade of F. suspense ，the contents of above indicators were ≥2.26％，≥0.41％，≥7.47％，≥32.58％ and ≤5.33％，respectively；in third grade of F. suspense ，the contents of above indicators were ≥2.15％，≥0.32％，≥4.60％，≥31.52％ and≤7.23％，respectively. |
| 期刊： | 2022年第33卷第07期 |
| 作者： | 韦智江，任晓红，张烨，代熙，郭然，赵梓邯，刘路路，刘勇，李卫东 |
| AUTHORS： | WEI Zhijiang ，REN Xiaohong ，ZHANG Ye，DAI Xi，GUO Ran，ZHAO Zihan，LIU Lulu，LIU Yong，LI Weidong |
| 关键字： | 青翘；质量等级；AHP-PCA混合加权法 |
| KEYWORDS： | premature Forsythia suspensa ；quality grade ；AHP-PCA mixed weighting method |
| 阅读数： | 1014 次 |
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