乌药汤挥发性成分提取工艺的优化-中国药房

乌药汤挥发性成分提取工艺的优化

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篇名：	乌药汤挥发性成分提取工艺的优化
TITLE：	Optimization of the extraction technology of volatile components from Wuyao decoction
摘要：	目的优化经典名方乌药汤挥发性成分的提取工艺。方法在单因素实验的基础上，以有效成分乙酸龙脑酯、香附烯酮、α-香附酮、藁本内酯、去氢木香内酯含量及挥发油提取率的综合评分为指标，以提取时间、浸泡时间、液料比为响应因素，采用Box-Behnken设计-响应面法优化乌药汤挥发性成分的提取工艺并验证。在此基础上，再对药液的提取状态进行量化。结果最优提取工艺为液料比13∶1（mL/g），浸泡时间0.5h，暴沸状态下提取6h。3次验证实验的综合评分分别为0.9487、0.9484、0.9486（RSD＝0.02％，n＝3），与预测值（0.9479）的偏差均不超过1％。以180℃油浴下药液的沸腾状态作为暴沸状态。结论所得乌药汤挥发性成分最优提取工艺稳定、可行。
ABSTRACT：	OBJECTIVE To optimize the extraction technology of volatile components from Wuyao decoction. METHODS On the basis of single factor investigation ，the extraction technology of volatile components from Wuyao decoction was optimized and validated by Box-Behnken design-response surface technology using the contents of bomyl acetate ，cyperotundone，α-cyperone， ligustilide and dehydrocostuslactone ， extraction rate of volatile oil as indexes ， with extraction time ， soaking time and liquid-material ratio as factors. On this basis ，the extraction state of the decoction was quantified. RESULTS The optimal extraction technology was as followed ：the ratio of liquid -material was 13∶1（mL/g），soaking time was 0.5 h，and the extraction time was 6 h in the boiling state. The comprehensive scores of the three validation experiments were 0.948 7，0.948 4 and 0.948 6 respectively （RSD＝0.02％，n＝3），and the deviation from the predicted value （0.947 9）was no more than 1％. The boiling state of the decoction in 180 ℃ oil bath was taken as the sudden boiling state. CONCLUSIONS The optimized extraction technology is stable and feasible.
期刊：	2022年第33卷第06期
作者：	程媛，孙吴倩，刘明松，邓亚伟，段续红，李春花
AUTHORS：	CHENG Yuan，SUN Wuqian ，LIU Mingsong ，DENG Yawei ，DUAN Xuhong ，LI Chunhua
关键字：	乌药汤；挥发性成分；提取工艺；Box-Behnken设计-响应面法
KEYWORDS：	Wuyao decoction ；volatile components ；extraction technology ；Box-Behnken design-response surface technology
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