栀子中环烯醚萜类成分抗阿尔茨海默病的作用机制研究进展
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篇名: 栀子中环烯醚萜类成分抗阿尔茨海默病的作用机制研究进展
TITLE: Research progress on the mechanism of iridoids from Gardenia jasminoides against Alzheimer ’s disease
摘要: 阿尔茨海默病(AD)是一种常见的隐匿性神经退行性疾病,以认知障碍、学习和记忆功能损失、行为能力反常、痴呆等为主要特征,目前尚无特效药物能够有效阻止或逆转AD。栀子为茜草科栀子属植物栀子GardeniajasminoidesJ.Ellis的干燥成熟果实,化学成分主要包括环烯醚萜类、三萜类、有机酸类和挥发油类,其中环烯醚萜类为栀子的主要活性成分。本文就近年来国内外对栀子环烯醚萜类成分抗AD的作用机制研究进行梳理归纳,以期为抗AD的新药开发提供参考。
ABSTRACT: Alzheimer’s disease (AD)is a common latent neurodegenerative disease ,which is characterized by cognitive impairment,loss of learning and memory function ,abnormal behavior and dementia. At present ,there is no specific drug to effectively prevent or reverse AD. Gardenia jasminoides is the dried and mature fruit of G. jasminoides J. Ellis ,a gardenia plant in Rubiaceae. Its chemical components mainly include iridoids ,triterpenoids,organic acids and volatile oils ,among which iridoids are the main active components of G. jasminoides . This paper summarizes the researches on the mechanism of iridoids from G. jasminoides against AD at home and abroad in recent years ,in order to provide reference for the development of new drugs against AD.
期刊: 2022年第33卷第01期
作者: 付庆,单淇,周钰通,杨冰,岳钰茗,蒋沅岐,周福军
AUTHORS: FU Qing,SHAN Qi,ZHOU Yutong ,YANG Bing,YUE Yuming ,JIANG Yuanqi ,ZHOU Fujun
关键字: 阿尔茨海默病;栀子;环烯醚萜类;京尼平苷;作用机制
KEYWORDS: Alzheimer’s disease ;Gardenia jasminoides ;iridoids;geniposide;mechanism
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