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吸入疗法治疗呼吸系统疾病的文献可视化分析
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| 篇名： | 吸入疗法治疗呼吸系统疾病的文献可视化分析 |
| TITLE： | Document Visualization Analysis of Inhalation Therapy for Respiratory Diseases |
| 摘要： | 目的：探究吸入疗法治疗呼吸系统疾病的全球研究现状和研究热点，为我国未来该领域的进一步发展提供参考。方法：检索WebofScience数据库中自建库起至2020年1月1日的有关吸入疗法治疗呼吸系统疾病的所有文献。运用WebofScience自带的检索结果分析功能并结合CiteSpace5.1.R6SE软件的可视化分析功能，分别从年发文量、国家、机构、学科类别、共被引作者等方面分析该领域的研究情况；对关键词绘制知识图谱，并进行聚类分析和突发性探测，分析该领域的研究热点及发展进程。结果：共纳入1385篇文献。1947－2020年的年发文量总体呈上升趋势；开展相关研究的国家有66个，美国处于领先地位（发文量占总发文量的33.79％），其次为德国和英国（发文量分别占总发文量的10.32％、8.88％），而我国在该领域的发文量仅占总发文量的3.75％；参与该类研究的机构涉及了呼吸疾病研究所、综合性大学和国家职业安全卫生研究所，其中排名靠前的主要为悉尼大学、北卡罗来纳大学、哈佛大学等；涉及学科类别包括分子生物学、内科学、药理学、工程学等多个领域；共被引作者共有749位，排名前2位的作者的共被引频次分别为109、84次。通过聚类分析得到了该领域中包括吸入给药的剂型及工艺设计、吸入用药物作用机制、吸入疗法用于呼吸系统阻塞性疾病、吸入疗法用于呼吸系统感染性疾病、吸入疗法用于呼吸系统疾病的特殊人群、吸入疗法用于呼吸系统疾病的危险因素等6大研究热点。通过突发性探测发现，在20世纪90年代初期该领域研究非常活跃，接连出现了多个研究热点。在21世纪初期也短暂地出现了几个新的研究热点，如计量吸入器、气溶胶等，至21世纪20年代，相继出现了纳米粒子、人体试验等研究热点。结论：吸入疗法治疗呼吸系统疾病的研究在国际上一直呈稳步上升趋势，而我国在该领域的研究还十分有限。未来我国可关注国际上该领域的研究热点与方向，进一步加强与其他国家的交流与合作。 |
| ABSTRACT： | OBJECTIVE：To investigate the research status and hotspots of inhalation therapy for respiratory diseases in the world，and to provide reference for further development of the filed in China. METHODS ：All literatures about inhalation therapy for respiratory disease were retrieved from Web of Science database from the inception to Jan. 1st，2020. The retrieval result analysis function of Web of Science combined with visual analysis function of CiteSpace 5.1.R6SE software were used to analyze included literatures from respective of annual number of articles published ，countries，institutions，categories and co-cited authors ， so as to analyze the research situation in this field. The knowledge map of key words was drawn ，then cluster analysis and burst detection were carried out ，and the research hotspot and development process were analyzed. RESULTS ：A total of 1 385 literatures were included. From 1947 to 2020，the overall trend of annual number of articles published was on the rise. There were 66 countries involved in relevant research ，the United States was in the leading position （the number of articles published accounting for 33.79％ of total articles published ），followed by Germany and UK （the number of articles published accounting for 10.32％， 8.88％ of total articles published ），while Chinese number of articles published accounting for only 3.75％ of total articles published. Institutions involved in this research field included the respiratory diseases research institution ，comprehensive universities and national institute for occupational safety health ；top ranked institutions were Sydney University ，North Carolina University， Harvard University ， etc. The subject category involved molecular biology ， internal medicine ， pharmacology， engineering and other fields. A total of 749 authors were co-cited ，and the co-cited frequency of top two authors were 109，84 times respectively. Through the cluster analysis ，6 major researches hotspots were obtained in this field ，including the dosage form and technology design of inhaled drugs ，the mechanism of inhaled drugs ，the application of inhalation therapy for the obstructive diseases of respiratory system ，the application of inhalation therapy for the infectious diseases of respiratory system ，the application of inhalation therapy for the special population of respiratory diseases，and the risk factors in the application of inhalation （No.2017YFC0909900） therapy for respiratory diseases. Through the sudden detection ， it was found that in the early 1990s，the research in this field was very active ，and there were many research hotspots ；in the early 21st century ， there were several new research hotspots for a short time ，such as metered-dose inhaler ，aerosol，etc.；till the 2020s，there were many research hotspots ，such as nanoparticles，human trials ，etc. CONCLUSIONS ：Researches about inhalation therapy for the respiratory diseases are steadily increasing internationally ，while the researches in this field in China is still very limited. In the future ，our country can pay attention to the international research hotspot and direction in this field ，and further strengthen the exchanges and cooperation with other countries. |
| 期刊： | 2020年第31卷第13期 |
| 作者： | 刘冲，乔高星，楚尧娟，苏冉，赵杰，杜书章 |
| AUTHORS： | LIU Chong ，QIAO Gaoxing ，CHU Yaojuan ，SU Ran，ZHAO Jie，DU Shuzhang |
| 关键字： | 吸入疗法；呼吸系统疾病；研究热点；发展进程；文献可视化分析 |
| KEYWORDS： | Inhalation therapy ；Respiratory diseases ；Research hotspots ；Development process ；Document visualization |
| 阅读数： | 382 次 |
| 本月下载数： | 8 次 |
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