异甘草酸镁预防胃癌化疗药物致肝损伤的药物经济学评价
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篇名: 异甘草酸镁预防胃癌化疗药物致肝损伤的药物经济学评价
TITLE: Pharmacoeconomic Evaluation of Magnesium Isoglycyrrhizinate Preventing Liver Damage Induced by Chemo- therapeutic Drugs for Gastric Cancer
摘要: 目的:评价异甘草酸镁预防胃癌化疗药物致肝损伤的药物经济学,为临床合理选用保肝药提供参考。方法:回顾性收集2018年1月-2020年2月我院200例住院患者的病历,分为A组(预防性使用异甘草酸镁,50例)、B组(预防性使用异甘草酸镁联合中药协定方,50例)、C组(预防性使用多烯磷脂酰胆碱,50例)和D组(未预防性使用保肝药,50例)。比较4种方案预防肝损伤的效果(总有效率),采用最小成本法和成本-效果分析法进行经济学评价,同时进行敏感性分析。结果:A、B、C、D组患者总有效率分别为94.00%、96.00%、82.00%、72.00%,A组和B组患者的总有效率比较差异无统计学意义(P>0.05),但显著高于C组和D组(P<0.05);C组患者总有效率显著高于D组(P<0.05)。A、B、C、D组的成本分别为1936.70、2086.96、1800.91、2975.42元,采用最小成本法比较A组和B组方案,结果A组方案更经济;采用成本-效果法比较C组和D组方案,结果C组方案更经济;采用成本-效果法比较A组和C组方案,结果两组方案的成本-效果比分别为2060.32、2196.23,A组方案的增量成本-效果比为1131.58,A组方案更经济。敏感性分析支持上述结果。结论:异甘草酸镁预防胃癌化疗药物致肝损伤的成本-效果优于异甘草酸镁联合中药协定方、多烯磷脂酰胆碱和未预防性使用保肝药,更具经济学优势。
ABSTRACT: OBJECTIVE:To ev aluate pha rmacoeconomics of magnesium isoglycyrrhizinate preventing liver damage induced by chemotherapeutic drugs for gastric cancer ,and to provide reference for rational use of liver-protecting drugs. METHODS :Totally 200 inpatient medical records were collected from our hospital retrospectively during Jan. 2018-Feb. 2020,and then divided into group A (prophylactic use of magnesium isoglycolate ,50 cases),group B (prophylactic use of magnesium isoglycolate combined with TCM prescriptions ,50 cases),group C (prophylactic use of polyene phosphatidylcholine ,50 cases) and group D (non-prophylactic use of liver-protection drugs ,50 cases). The effects (total response rate )of four plans preventing liver damage were evaluated. Pharmacoeconomic evaluation was analyzed by cost-minimization analysis and cost-effectiveness method , sensitivity analysis was carried out at the same time . RESULTS :Total response rates of group A ,B,C and D were 94.00%, 96.00%,82.00% and 72.00%. The total response rates of group A and B had no statistical significance (P>0.05),but were significantly higher than those of group C and D (P<0.05);total response rate of group C was significantly higher than that of group D (P<0.05). The costs of groups A ,B,C and D were 1 936.70,2 086.96,1 800.91,2 975.42 yuan. The cost-minimization analysis was used to compare the therapeutic plan of group A and B ,and plan of group A was more economical. The cost-effectiveness method was used to compare therapeutic plan between group C and D ,and the plan of group C was more economical. The cost-effectiveness method was used to compare therapeutic plan between group A and C ,and the cost-effectiveness ratio of 2 groups were 2 060.32 and 2 196.2 3,incremental cost-effectiveness ratio was 1 131.58,and the plan of group A was more economical. Above conclusion were supported by the results of sensitivity analysis. CONCLUSIONS :The cost-effectiveness of magnesium isoglycyrrhizinate preventing liver damage induced by chemotherapeutic drugs for gastric cancer is better than magnesium isoglycyrrhizinate combined with TCM prescription , polyene phosphatidylcholine and non-prophylactic use of liver-protecting drugs ,showing economical advantage.
期刊: 2020年第31卷第13期
作者: 任发燕,王超,谭喜莹,王海丹
AUTHORS: REN Fayan,WANG Chao,TAN Xiying ,WANG Haidan
关键字: 异甘草酸镁;药物性肝损伤;胃癌;化疗药物;药物经济学
KEYWORDS: Magnesium isoglycyrrhizina te;Drug-induced liver damage ;Gastic cancer ;Chemotherapeytic drug ;Pharmacoeconomics
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