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基于Apriori算法和“味性化味”矢量模型的含石榴子藏药方剂的用药规律及药性研究
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| 篇名： | 基于Apriori算法和“味性化味”矢量模型的含石榴子藏药方剂的用药规律及药性研究 |
| TITLE： | Study on Medication Regulation and Pharmaceutical Property of Tibetan Medicine Prescription of Punica gran- atum Seeds Based on Apriori Algorithm and “Ro Nus Zhu rJes ”Vector Model |
| 摘要： | 目的：探讨含石榴子藏药方剂的用药规律，分析其治疗“三胃火”功能失调致相关疾病的药性特点。方法：以《藏医临床札记》《卫生部药品标准·藏药》等为标准，收集《四部医典》《月王药诊》等医籍中记载的含石榴子的藏药方剂，运用中医传承辅助平台（TCMISSV2.5）统计其主治疾病、药材频次；运用Apriori算法挖掘方剂中的核心药材组合（支持度≥50％、置信度≥90％），并分析其用药规律；应用“味性化味”矢量结构模型分析含石榴子藏药方剂治疗高频疾病的药性，并对十七效进行K均值聚类分析。结果：共收集含石榴子的藏药方剂300首，涉及主治疾病104种，频次≥10次的有18种，包括不消症（76次）、木布病（46次）、浮肿（34次）等。涉及药材322味，使用频次≥50次的共21味，包括荜茇（192次）、豆蔻（164次）、红花（134次）等。共得核心药材组合56个，以石榴子-荜茇（192次）、石榴子-豆蔻（164次）、石榴子-红花（134次）为主。治疗不消症含石榴子藏药方剂（13首）的六味以辛、甘、酸为主，具糙、热、干效等药性，归为Ⅰ类；治疗木布病方剂（13首）的六味以苦、甘、辛为主，具凉、钝、重效等药性，归为Ⅱ类；治疗浮肿方剂（11首）的六味以甘、酸、辛为主，具重、钝、润效等药性，归为Ⅲ类。结论：藏药石榴子常与荜茇、豆蔻等温性药材联用，也可见于凉性方剂中，符合藏医治疗注重“三胃火”的用药规律，也体现了藏医药“温中有凉，凉中含温”的学术思想。 |
| ABSTRACT： | OBJECTIVE：To invest igate the medication regulation of Tibetan medicine prescription of Punica granatum seeds， and to analyze the pharmaceutical property of it in the treatment of “Sanweihuo”（Me drod gusm) dysfunction induced-related diseases. METHODS ：Using Clinical Notes of Tibetan Medicine ，Medicine Standard of the Ministry of Public Health ：Tibetan Medicine as standard ，Tibetan medicine prescriptions of P. granatum seeds recorded in Sibu Yidian ，Yuewang Yaozhen and other medical records were collected ，and TCMISS V 2.5 software was used to analyze main indication and medicine frequency statistically. The core medicine combinations of the prescriptions were analyzed with Apriori algorithm （support degree ≥50％， confidence degree ≥90％)，and medication regulations were analyzed. Tibetan medicine “Ro Nus Zhu rJes ”vector model was used to analyze the properties of Tibetan medicine prescription of P. granatum seeds in the treatment of high frequency diseases ，and K-means cluster analysis was carried out for seventeen effectiveness. RESULTS ：A total of 300 Tibetan medicine prescriptions of P. granatum seeds were collected ，involving 104 kinds of main indications ，among which frequency of 18 kinds of indications was more than or equal to 10 times，including“non-indigestion syndrome ”（Ma Zhu ba) （76 times)，“wood cloth disease ”（Smug po) （46 times)，“edema”（Chu nad) （34 times)，etc. Totally 322 kinds of Tibetan medicines were involved. Among them ，21 flavors were more than or equal to 50 in frequency ，including Piper longum （192 times)，Amomum kravanh （164 times) and Carthamus tinctorius（134 times)，etc. Fifty-six core combinations were obtained ，mainly including P. granatum seeds-P. longum （192 times)， P. granatum seeds-A. kravanh （164 times) and P. granatum seeds-C. tinctorius （134 times). The prescriptions （13 pieces) with six flavors as pungent ，sweet and sour ，and with prominent medicinal properties such as roughness ，heat and dry effects could be used to treat “non-indigestion syndrome ”，and then included into type Ⅰ. The prescriptions （13 pieces) with six flavors as bitter ，sweet and pungent ，and with prominent medicinal properties such as cooling ，dull and heavy effects could be used to treat “wood cloth disease”，and then included into type Ⅱ. The prescriptions （11 pieces) with six flavors as sweet ，sour and pungent ，and with prominent medicinal properties such as dull ，heavy and moistening effects could be used to treat “edema”，and then included into type Ⅲ. CONCLUSIONS ：Tibetan medicine P. granatum seeds is often used in combination with the isothermal medicines such as P. longum ，A. kravanh . P. granatum seeds are also commonly found in cool prescriptions ，revealing that Tibetan medicine pays attention to “Sanweihuo”while treating diseases ，which embodies the academic thought of Tibetan medicine that “there is cooling in temperature ，and there is temperature in cooling ”. |
| 期刊： | 2020年第31卷第08期 |
| 作者： | 切尼项毛，才让吉，文成当智，任青措，降拥四郎，泽翁拥忠，南卡尖参，德洛 |
| AUTHORS： | Qieni Xiangmao， Cairangji，Wencheng Dangzhi，REN Qingcuo，Jiangyong Silang，Zeweng Yongzhong，Nanka Jianshen，Deluo |
| 关键字： | 藏药；石榴子；方剂；中医传承辅助平台；Apriori算法；用药规律；味性化味；药性 |
| KEYWORDS： | Tibetan medicine ；Punica granatum seeds；Prescription；TCMISS；Apriori algorithm ；Medication regulation ；Ro |
| 阅读数： | 414 次 |
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