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硝苯地平联合氯沙坦对高血压合并冠心病患者血压和肾功能的影响
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| 篇名： | 硝苯地平联合氯沙坦对高血压合并冠心病患者血压和肾功能的影响 |
| TITLE： | |
| 摘要： | 目的：探讨硝苯地平联合氯沙坦对高血压合并冠心病患者血压和肾功能的影响。方法： 150 例高血压合并冠心病患者随机均分为对照组和观察组。对照组患者给予硝苯地平缓释片30 mg，口服，每日1次；观察组患者在对照组治疗的基础上给予氯沙坦钾胶囊50 mg，口服，每日1次。两组患者疗程均为1个月。观察两组患者治疗前后收缩压、舒张压、肾功能指标及不良反应发生情况。结果：治疗后，两组患者治疗3个月后收缩压、舒张压＜治疗1个月＜同组治疗前，肾功能指标均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）；观察组患者不良反应发生率显著低于对照组，差异有统计学意义（P＜0.05）。结论：硝苯地平联合氯沙坦可较好地控制高血压合并冠心病患者的血压，保护肾功能，安全性较好。 |
| ABSTRACT： | OBJECTIVE： To explore the effect of nifedipine combined with losartan on the blood pressure and renal function of hypertension complicated with coronary heart disease. METHODS： 150 patients with hypertension complicated with coronary heart disease were randomly divided into observation group and control group. Control group was orally treated with Nifedipine sustained release tablet 30 mg， once a day； observation group was additionally treated with Losartan potassium capsules 50 mg， once a day. The treatment course for both groups was 1 month. Systolic blood pressure， diastolic blood pressure， renal function indicators before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： After treatment， systolic blood pressure and diastolic blood pressure after 3 months was lower than 1 month and lower than before treatment in same group， renal function indicators were significantly lower than before treatment， and observation group was lower than control group， the differences were statistically significant（P＜0.05）； the incidence of adverse reactions in observation group was significantly lower than control group， the difference was statistically significant （P＜0.05）. CONCLUSIONS： Nifedipine combined with losartan can well control the blood pressure of hypertension complicated with coronary heart disease， protect renal functions， with good safety. |
| 期刊： | 2015年第26卷第36期 |
| 作者： | 吴超，王伊敏，吴丽娟，范莼，胡峰 |
| AUTHORS： | WU Chao，WANG Yi-min，WU Li-juan，FAN Chun，HU Feng |
| 关键字： | 硝苯地平；氯沙坦；高血压；冠心病；肾功能 |
| KEYWORDS： | Nifedipine； Losartan； Hypertension； Coronary heart disease； Renal functions |
| 阅读数： | 217 次 |
| 本月下载数： | 2 次 |
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