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阿司匹林联合跌打化瘀散预防大隐静脉曲张术后深静脉栓形成的临床观察
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| 篇名： | 阿司匹林联合跌打化瘀散预防大隐静脉曲张术后深静脉栓形成的临床观察 |
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| 摘要： | 目的：观察阿司匹林联合跌打化瘀散预防大隐静脉曲张术后深静脉栓的疗效和安全性。方法： 280例拟行大隐静脉曲张术患者随机均分为对照组和观察组。对照组患者于术后第二天给予阿司匹林肠溶片100 mg，早饭后服用，每日1次；观察组患者在对照组治疗的基础上于术后第二天加用跌打化瘀散2 g，于足部及患肢非手术部位热敷。两组患者均以7 d为1个疗程。观察两组患者手术前后凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（Fg）、血小板计数，深静脉栓发生率及不良反应发生情况。结果：观察组患者深静脉栓发生率显著低于对照组，差异有统计学意义（P＜0.05）。术后，两组患者PT、APTT、Fg均显著高于同组术前，且观察组高于对照组；血小板计数均显著低于同组术前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：阿司匹林联合跌打化瘀散较单用阿司匹林可有效预防大隐静脉曲张术后深静脉栓的形成，抑制凝血，且安全性相当。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of aspirin combined with Dieda huayu powder in the prevention of deep vain thrombus （DVT） after great saphenous varicose vein surgery. METHODS： 280 patients with great saphenous vein surgery were randomlt divided into control group and observation group. control group was given Aspirin enteric-coated tablet 100 mg breakfast in the next day of surgery， once a day； observation group was additionally given Diedahuayu powder 2 g to fumigate feet and non-operation place on ill leg in the next day of surgery. 7 d was a treatment course. The incidence of prothrombin time （PT）， activated partial thromboplastin time （APTT）， fibrinogen （Fg）， platelet count and the incidence of DVT and adverse reactions after surgery before and after surgery in 2 groups were observed. RESULTS： The incidence of DVT in observation group was significantly lower than control group， the difference was statistically significant（P＜0.05）. After surgery， the PT， APTT and Fg in 2 groups were significantly higher than before， and observation group was higher than control group， platelet count was significantly lower than before， and observation group was lower than control group， the differences were statistically significant（P＜0.05）； there was no significant difference in the incidence of adverse reactions between 2 groups（P＞0.05）. CONCLUSIONS： Aspirin combined with Dieda huayu powder can more effectively prevent the DVT after great saphenous varicose vein surgery than only aspirin， inhibit coagulation， with similar safety. |
| 期刊： | 2015年第26卷第36期 |
| 作者： | 王俊莉，罗真春 |
| AUTHORS： | WANG Jun-li，LUO Zhen-chun |
| 关键字： | 阿司匹林；跌打化瘀散；大隐静脉曲张术；深静脉栓 |
| KEYWORDS： | Aspirin； Dieda huayu powder； Great saphenous varicose vein surgery； Deep vain thrombus |
| 阅读数： | 495 次 |
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