终末期肾脏病患者应用头孢他啶后并发抗生素脑病的相关性分析
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篇名: 终末期肾脏病患者应用头孢他啶后并发抗生素脑病的相关性分析
TITLE:
摘要: 目的:探讨终末期肾脏病(ESRD)患者应用头孢他啶后并发抗生素脑病的相关性。方法 :回顾性分析我院20例ESRD应用头孢他啶后并发抗生素脑病的患者资料,并作为观察组,同期选择20例ESRD应用头孢他啶后未并发抗生素脑病的患者资料作为对照组。观察组患者经停用头孢他啶2~5 d后,若未见好转,则进行血液透析串联血液灌流。监测观察组患者血红蛋白(Hb)、白蛋白(Alb)、血肌酐(Scr)、尿素氮(BUN)、总胆固醇(TC)、甘油三酯(TG)、甲状旁腺激素(PTH)水平,记录头孢他啶使用时间与累积剂量,并与对照组进行比较。结果 :观察组患者的年龄、头孢他啶使用时间、头孢他啶累积剂量均显著高于对照组,Alb水平显著低于对照组,差异均有统计学意义(P<0.05)。观察组患者经对症治疗后19例好转,1 例死亡。结论: ESRD患者应用头孢他啶后并发抗生素脑病与患者高龄、低Alb血症、头孢他啶使用时间及累积剂量具有相关性。
ABSTRACT: OBJECTIVE: To investigate the correlation of patients with end stage renal disease (ESRD) and antibiotics encephalopathy after giving ceftazidime. METHODS:Data of 20 ESRD patients with antibiotics encephalopathy were retrospectively analyzed and included into observation group, and also 20 ESRD patients with no antibiotics encephalopathy were included into control group. Patients with no improved conditions in observation group were given hemodialysis associated with hemoperfusion after 2-5 days of ceftazidime withdrawal. The hemoglobin (Hb), albumin (Alb), serum creatinine (Scr), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), parathyroid hormone (PTH), use time and cumulative dose of ceftazidime in observation group were detected and compared with control group. RESULTS:The age, use time and cumulative dose of ceftazidime in observation group were significantly higher than control group, Alb level was lower than control group, the differences were statistically significant(P<0.05). 19 patients in remission and 1 died in observation group. CONCLUSIONS:The antibiotic encephalopathy in ESRD patients has correlation with elderly, hypoalbuminemia, use time and cumulative dose of ceftazidime.
期刊: 2015年第26卷第36期
作者: 龚昌华,叶树位
AUTHORS: GONG Chang-hua,YE Shu-wei
关键字: 血液透析;终末期肾脏病;抗生素脑病;头孢他啶;相关性
KEYWORDS: Hemodialysis; End stage renal disease; Antibiotic encephalopathy; Ceftazidime; Correlation
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