目的：观察卡前列素氨丁三醇两种给药方式用于产后出血的疗效及安全性。方法：285 例产后出血产妇按随机数字表法

分为对照组（143 例）和试验组（142 例）。对照组产妇给予卡前列素氨丁三醇注射液250 μg 手臂三角肌肌内注射；试验组产妇给予

同等剂量的卡前列素氨丁三醇注射液宫颈注射。两组产妇均在第三产程后一次给药。观察两组产妇临床疗效、2 h 内子宫出血

量、阴道出血量以及产后不良反应发生率。结果：给药后两组产妇产后出血量均＜400 ml，未超过产后大出血的标准，差异无统计

学意义（P＞0.05）。试验组产妇的子宫出血量显著高于对照组，阴道出血量显著低于对照组，差异有统计学意义（P＜0.05）；试验

组不良反应发生率（4.90％）与对照组（6.31％）比较，差异无统计学意义（P＞0.05）。结论：子宫收缩乏力产妇产后出血采取手臂三

角肌肌内注射疗效较好，其他产妇产后出血采取宫颈注射疗效较好，且不良反应均较低。

OBJECTIVE：To observe therapeutic efficacy and safety of carboprost tromethamine in the treatment of postpartum

hemorrhage with two routes of administration. METHODS：285 patients with postpartum hemorrhage were randomly divided into

control group（143 cases）and trial group（142 cases）. Control group was given Carboprost tromethamine injection 250 μg on deltoid

of arm；trial group was given same dose of Carboprost tromethamine injection via cervix uteri. Both groups received medicine

after third stage of labor. The therapuetic efficacy，the amount of endometrorrhagia and colporrhagia within 2 h，the incidence of

ADR after labor were observed in 2 groups. RESULTS：After treatment，the amount of postpartum hemorrhage was smaller than

400 ml in 2 groups and didn’t exceed the standard，without statistical significance（P＞0.05）. The amount of endometrorrhagia in

trial group was significantly higher than in control group，with statistical significance（P＜0.05）；the amount of colporrhagia in trial

group was significantly lower than in control group，with statistical significance（P＜0.05）. There was no statistical significance

in the incidence of ADR between trial group（4.90％）and control group（6.31％）（P＞0.05）. CONCLUSIONS：The intramuscular

injection is selected for the prevention of postpartum hemorrhage caused by uterine inertia；the cervical injection is selected for the

prevention of postpartum hemorrhage caused for the other patients.