目的：探讨在常温与低温下贮存国产顺式阿曲库铵对临床时效的影响。方法：90 例择期全麻患者，按随机数字表法分为

低温组、常温A组及常温B组，各30 例。采用TOF-Watch SX肌松监测仪单次超强电刺激观察上肢拇收肌的肌松程度，待患者麻

醉诱导意识消失后静脉注射顺式阿曲库铵0.2 mg/kg，当肌颤搐降到最大抑制程度时行气管插管。低温组患者所用顺式阿曲库铵

置于冰箱2～5 ℃贮存，常温A组与常温B组患者所用顺式阿曲库铵置于30 ℃的恒温箱中分别贮存15 d 和30 d。记录3 组患者起

效时间、肌颤搐最大抑制程度、临床作用时间、恢复指数及总时效。结果：3 组患者在顺式阿曲库铵的作用下肌颤搐的最大抑制程

度均达到0。常温A组和常温B组患者起效时间及临床作用时间与低温组比较，差异均无统计学意义（P＞0.05）；常温A组和常温

B组患者恢复指数及总时效均长于低温组，差异有统计学意义（P＜0.05）。结论：国产顺式阿曲库铵应在低温下贮存，对肌松效应

影响较小。

OBJECTIVE： To observe the effect of room temperature and low temperature storage on the chronergy of domestic

cisatracurium. METHODS：90 patients undergoing elective surgery under general anesthesia were randomly divided into low temperature

group，room temperature A group and room temperature B group，with 30 cases in each groups. Through single supramaximal

electrical stimulation of the adductor pollicis muscle，TOF-Watch SX muscle relaxation monitor was used to observe the degree

of muscle relaxation. After induction of anesthesia and lost consciousness，the patients was given intravenous injection of cisatracurium

0.2 mg/kg；when muscle twitch decreased to the maximum inhibition degree，the patient received endotracheal intubation. The

cisatracurium of low temperature group was stored in refrigerator at 2 to 5 ℃；that of room temperature A group and room temperature

B group was stored in incubator for 15 days or 30 days. The onset time，maximum inhibition degree of muscle twitch，clinical

duration，recovery index and total chronergy were recorded in 3 groups. RESULTS：The maximal inhibition degree of muscle

twitch reached 0 under the action of cisatracurium. There was no statistical significance in onset time and clinical duration between

room temperature A group，room temperature B group and low temperature group（P＞0.05）；the recovery index and total chronergy

of room temperature A group and room temperature B group were or longer than low temperature group，with statistical significance（

P＜0.05）. CONCLUSIONS：Domestic cisatracurium stored at low temperature shows weaker effect on muscle relaxation.