目的：探讨氟比洛芬酯对胃癌根治术后吗啡用量及患者肠功能恢复的影响。方法：102 例胃癌根治术患者按随机数字表

法分为对照组和观察组，各51 例。对照组患者给予常规硬膜外吗啡自控镇痛泵镇痛，观察组患者在此基础上分别于术前及术后

24 h 静脉注射氟比洛芬酯50 mg。观察并记录两组患者疼痛视觉模拟评分法（VAS）评分、舒适度评分法（BCS）评分、吗啡用量及

肠功能恢复情况。结果：两组患者术后48 hVAS评分、BCS评分比较差异均无统计学意义（P＞0.05），但观察组患者吗啡用量明显

少于对照组，差异有统计学意义（P＜0.05）；观察组患者术后肠鸣音恢复时间与第1 次肛门排气时间均显著早于对照组，且观察组

患者术后恶心呕吐发生率明显低于对照组，差异有统计学意义（P＜0.05）。结论：胃癌根治术患者应用氟比洛芬酯协同吗啡镇痛

可在达到相同镇痛效果的基础上减少吗啡用量，降低吗啡的不良反应，并且有利于患者术后肠功能恢复。

OBJECTIVE：To investigate the effect of flurbiprofen on morphine doses and intestinal function recovery after radical

gastrectomy for gastric cancer. METHODS：102 patients underwent radical gastrectomy of gastric cancer were randomly divided

into control group and observation group，with 51 cases in each group. Control group was treated with routine morphine analgesia

pump，and observation group was additionally given intravenous injection of flurbiprofen 50 mg before operation and 24 h after operation

on the basis of control group. VAS，comfort score（BCS），the amount of morphine and intestinal function recovery were observed

and recorded in 2 groups. RESULTS：48 h after operation，there was no statistical significance in VAS and BCS scores between

both groups（P＞0.05），but the dose of morphine in observation group was significantly less than in control group，with statistical

significance （P＜0.05）；the postoperative recovery time of bowel sounds and the first anal exhaust time in observation

group were significantly shorter than control group，and the incidence of nausea and vomiting in observation group was significantly

lower than control group，with statistical significance（P＜0.05）. CONCLUSIONS：The application of flurbiprofen combined

with morphine in gastrectomy can reduce the dose and ADR of morphine based on the same analgesic effect，and it is good for the

recovery of intestinal function.