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白藜芦醇-羟丙基-β-环糊精-壳聚糖缓释微球的制备及表征
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| 篇名： | 白藜芦醇-羟丙基-β-环糊精-壳聚糖缓释微球的制备及表征 |
| TITLE： | |
| 摘要： | 目的：制备白藜芦醇（RES）-羟丙基-β-环糊精（HP-β-CD）-壳聚糖缓释微球（RES-HP-β-CD-Chitosan），并进行表征。方法：按质量比1 ∶ 7 ∶ 0.25称取RES原料药、HP-β-CD和壳聚糖，先采用溶剂法制备RES-HP-β-CD包合物，在此基础上加入壳聚糖，采用喷雾干燥法制得RES-HP-β-CD-Chitosan。采用光学显微镜观察所制缓释微球的粒径。采用X射线衍射法、差式扫描量热法、红外光谱法、扫描电子显微镜对所制RES-HP-β-CD-Chitosan进行表征。采用紫外分光光度法测定所制缓释微球中RES的含量，计算载药量和包封率。结果：所制RES-HP-β-CD-Chitosan的粒径为（2.23±0.35） μm（n＝300），表征结果显示，RES-HP-β-CD-Chitosan呈球形，微球表面出现收缩褶皱，RES被包合于羟丙基-β-环糊精中，以分子状态或无定型状态存在。RES-HP-β-CD-Chitosan的载药量为11.67％（n＝3）、包封率为96.27％（n＝3）。结论：成功制得RES-HP-β-CD-Chitosan。 |
| ABSTRACT： | OBJECTIVE： To prepare Resveratrol-hydroxypropyl-β-cyclodextrin-chitosan sustained-release pellets （RES-HP-β- CD-Chitosan）， and to characterize it. METHODS： Resveratrol raw material， HP-β-cyclodextrin and chitosan were collected with ratio of 1 ∶ 7 ∶ 0.25. Resveratrol-HP-β-cyclodextrin inclusion compound were prepared by solvent method， and then added into chitosan， RES-HP-β-CD-Chitosan were prepared by spray drying method. Particle size of prepared sustained-released pellets were observed by optical microscope. X-ray， DSC， IR and SEM were used to characterize RES-HP-β-CD-Chitosan. The contents of resveratrol in prepared sustained-released pellets were determined by UV spectrum， and drug-loading amount and encapsulation efficiency were calculated. RESULTS： Particle size of prepared RES-HP-β-CD-Chitosan was （2.23±0.35） μm （n＝300）. Characterization results show that RES-HP-β-CD-Chitosan was spherical in shape； shrinkage was found on the surface of microspheres， and resveratrol was included in HP-β-cyclodextrin in molecule or amorphous state. Drug-loading amount of prepared RES-HP-β-CD-Chitosan was 11.67％ （n＝3）， encapsulation efficiency was 96.27％ （n＝3）. CONCLUSIONS： RES-HP-β-CD- Chitosan is prepared successfully. |
| 期刊： | 2019年第30卷第17期 |
| 作者： | 张纯刚，于琛琛，周旖璇，尹丽，程岚，康廷国，韩岚 |
| AUTHORS： | ZHANG Chungang，YU Chenchen，ZHOU Yixuan，YIN Li，CHENG Lan，KANG Tingguo，HAN Lan |
| 关键字： | 白藜芦醇；羟丙基-β-环糊精；壳聚糖；制备；表征 |
| KEYWORDS： | Resveratrol； Hydroxypropyl-β-cyclodextrin； Chitosan； Preparation； Characterization |
| 阅读数： | 557 次 |
| 本月下载数： | 10 次 |
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