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氟尿嘧啶联合对乙酰氨基酚治疗膝骨性关节炎的疗效和安全性及对相关指标的影响
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| 篇名： | 氟尿嘧啶联合对乙酰氨基酚治疗膝骨性关节炎的疗效和安全性及对相关指标的影响 |
| TITLE： | |
| 摘要： | 目 的：观察氟尿嘧啶联合对乙酰氨基酚治疗膝骨性关节炎的疗效和安全性及对相关指标的影响。方法：选取2015年3月－2018年3月我院收治的115例膝骨性关节炎患者，按用药方案的不同分为对照组（57例）和观察组（58例）。对照组患者给予对乙酰氨基酚片0.3 g，口服，每日3次，连用8周；观察组患者在对照组治疗的基础上给予氟尿嘧啶注射液0.075 g，关节腔内注射，每周1次，4次为1个疗程，共治疗2个疗程。观察两组患者的临床疗效，治疗前后的视觉模拟评分（VAS）、Lysholm膝关节评分、Fugl-Meyer运动功能积分法（FMA）评分、Barthel指数、世界卫生组织（WHO）生存质量测定表（QOL-BREF）评分及不良反应发生情况。结果：观察组患者总有效率为94.83％，显著高于对照组的78.95％（P＜0.05）。治疗前，两组患者VAS评分、Lysholm膝关节评分、FMA评分、Barthel指数及QOL-BREF评分比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者VAS评分均显著低于同组治疗前，且观察组显著低于对照组；Lysholm膝关节评分、FMA评分、Barthel指数及QOL-BREF评分均显著高于同组治疗前，且观察组显著高于对照组 （P＜0.05）。两组患者不良反应发生率比较差异无统计学意义（P＞0.05），且治疗期间均未见严重不良反应发生。结论：氟尿嘧啶联合对乙酰氨基酚可显著提高膝骨性关节炎患者的疗效，可改善其膝关节功能、运动功能、生活自理能力和生活质量，且未增加不良反应的发生。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of fluorouracil combined with paracetamol in the treatment of knee osteoarthritis and its effects on related indexes. METHODS： Totally 115 patients with knee osteoarthritis admitted to our hospital from March 2015 to March 2018 were divided into control group （57 cases） and observation group （58 cases） according to medication plan. Control group was given Paracetamol tablets 0.3 g orally， 3 times a day， for consecutive 8 weeks. Observation group was additionally given intra-articular injection of Fluorouracil injection 0.075 g on the basis of control group， once a week， 4 times as a treatment course， for 2 courses in total. Clinical efficacies， VAS scores， Lysholm knee scores， Fugl-Meyer Assessment （FMA） scores， Barthel indexes， WHO QOL-BREF scores before and after treatment and the occurrence of ADR of 2 groups were observed. RESULTS： The total response rate of observation group was 94.83％， which was significantly higher than 78.95％ of control group （P＜0.05）. Before treatment， there was no statistical significance in VAS score， Lysholm knee scores， FMA scores， Barthel index or QOL-BREF scores between 2 groups （P＞0.05）. After treatment， VAS scores of 2 groups were significantly lower than before treatment， and the observation group was lower than the control group； Lysholm knee scores， FMA scores， Barthel indexes and QOL-BREF scores were significantly higher than the same group before treatment， and observation group was significantly higher than control group （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. No severe ADR was found in 2 groups during treatment. CONCLUSIONS： Fluorouracil combined with paracetamol can significantly improve therapeutic efficacy of patients with knee osteoarthritis， and can significantly improve knee function， motor function， self-care ability and quality of life without increasing the occurrence of ADR. |
| 期刊： | 2019年第30卷第2期 |
| 作者： | 任少琳，彭磊，程少文，蒋翠芸 |
| AUTHORS： | REN Shaolin，PENG Lei，CHENG Shaowen，JIANG Cuiyun |
| 关键字： | 氟尿嘧啶；对乙酰氨基酚；关节腔内注射；膝骨性关节炎；疗效；安全性；膝关节功能；运动功能；生活自理能力；生活质量 |
| KEYWORDS： | Fluorouracil； Paracetamol； Intra-articular injection； Knee osteoarthritis； Efficacy； Safety； Knee function； Motor function； Self-care ability； Quality of life |
| 阅读数： | 375 次 |
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