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Box-Behnken响应面法优化穿心莲内酯自微乳的制备工艺
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| 篇名： | Box-Behnken响应面法优化穿心莲内酯自微乳的制备工艺 |
| TITLE： | |
| 摘要： | 目的：优化穿心莲内酯自微乳的制备工艺。方法：以外观、滴入水相中颜色为指标筛选乳化剂、助乳化剂、油相种类；以伪三元相图筛选各基质的用量范围；以粒径、分散指数、平衡溶解度为考察指标，以综合评分为响应值，以乳化剂质量分数、助乳化剂质量分数、油相质量分数为响应因子，采用Box-Behnken响应面法优化穿心莲内酯自微乳的制备工艺。结果：优化的穿心莲内酯自微乳制备工艺以聚氧乙烯氢化蓖麻油为乳化剂，二乙二醇单乙基醚为助乳化剂，油酸聚乙二醇甘油酯为油相，三者质量比为40 ∶ 59 ∶ 10。在此工艺条件下制得的自微乳粒径为（38.15±1.56）nm、分散指数为0.12±0.01、平衡溶解度为（5.97±0.02）mg/mL，与预测值（39.72 nm、0.11、6.04 mg/mL）的相对误差分别为3.95％、3.54％、1.16％，实测值与预测值一致性良好。结论：优化所得穿心莲内酯自微乳制备工艺稳定、可行，适用于该制剂的制备。 |
| ABSTRACT： | OBJECTIVE： To optimize the preparation technology of Andrographolide self-microemulsion. METHODS： The types of emulsifier， co-emulsifer and oilphase were screened with appearance， color of them in water phase as indexes. The amount range of each matrix was screened by using pseudo-ternary phase diagram. The preparation technology of Andrographolide self-microemulsion was optimized by Box-Behnken response surface technology with particle size， dispersion index and equilibrium solubility as evaluation indexes， comprehensive score as response value， using mass fraction of emulsifier， mass fraction of co-emulsifier and mass fraction of oil phase as response factors. RESULTS： The optimal preparation technology of Andrographolide self-microemulsion included that polyoxyethylene hydrogen sesame oil as emulsifier， diethylene glycol mono ethyl ether as emulsifier， oleic acid polyethylene glycol glyceride as oil phase， with weight ratio of 40 ∶ 59 ∶ 10. Under the condition， particle size of obtained self-microemulsion was （38.15±1.56） nm， dispersion index was 0.12±0.01 and equilibrium solubility was （5.97±0.02） mg/mL， relative error of which to predicted value （39.72 nm， 0.11， 6.04 mg/mL） were 3.95％， 3.54％， 1.16％. The measured value was in good agreement with the predicted value. CONCLUSIONS： The optimal Andrographolide self- microemulsion is stable， feasible and suitable for the preparation of the self-microemulsion. |
| 期刊： | 2018年第29卷第24期 |
| 作者： | 龙凯花，王春柳，李晔，张红，刘洋，孙婷婷，宗时宇 |
| AUTHORS： | LONG Kaihua，WANG Chunliu，LI Ye，ZHANG Hong，LIU Yang，SUN Tingting，ZONG Shiyu |
| 关键字： | 穿心莲内酯；自微乳；制备工艺；Box-Behnken响应面法；伪三元相图；粒径；分散指数；平衡溶解度 |
| KEYWORDS： | Andrographolide； Self-microemulsion； Preparation technology； Box-Behnken response surface methodology； Pseudo-ternary phase diagram； Particle size； Dispersion index； Equilibrium solubility |
| 阅读数： | 276 次 |
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