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紫及纳米乳的药效学研究
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| 篇名： | 紫及纳米乳的药效学研究 |
| TITLE： | |
| 摘要： | 目的：观察紫及纳米乳（ABN）的抗炎、镇痛、止血及促进伤口愈合作用。方法：以云南白药为阳性对照，将动物随机分为空白组（水或生理盐水）、YB组（云南白药溶液，小鼠给药剂量为0.065 g/kg，家兔给药剂量为0.023 3 g/kg）和ABN组（小鼠给药剂量为0.065 g/kg，家兔给药剂量为0.023 3 g/kg）。小鼠实验均为每组10只；家兔实验共9只，每只按伤口进行分组。采用二甲苯致小鼠耳廓肿胀实验和蛋清致小鼠足趾肿胀实验考察ABN的抗炎作用；采用热板致小鼠足趾疼痛实验和醋酸致小鼠扭体反应实验考察ABN的镇痛作用；采用小鼠断尾止血实验考察ABN的止血作用；采用家兔促进皮肤伤口愈合实验考察ABN的促进伤口愈合作用。结果：与空白组比较，ABN能够显著减轻二甲苯致小鼠耳廓肿胀、蛋清致小鼠足趾肿胀（P＜0.05）；能够显著延长热板致小鼠足趾疼痛的痛阈值，减少醋酸致小鼠扭体反应次数（P＜0.05）；能够显著缩短小鼠断尾出血时间（P＜0.05）；能够加快家兔皮肤伤口愈合。上述作用大多与云南白药相当，甚至在抗炎和促进伤口愈合方面更优。结论：ABN具有良好的抗炎、镇痛、止血及促进伤口愈合作用。 |
| ABSTRACT： | OBJECTIVE： To investigate the anti-inflammatory， analgesic， hemostasis and healing promotion effect of Arnebia Bletilla nanoemulation （ABN）. METHODS： Using Yunnan Baiyao as positive control， experimental animals were randomly divided into blank group （water or normal saline）， YB group （Yunnan Baiyao solution， 0.065 g/kg for mice， 0.023 3 g/kg for rabbits） and ABN group （ABN， 0.065 g/kg for mice， 0.023 3 g/kg for rabbits）. The experiments in mice were grouped with 10 mice each；the experiment in rabbits was grouped by wound in 9 rabbits. The anti-inflammatory effects of ABN were studied by auricular swelling induced by xylene and toe swelling induced by albumen in mice. Analgesic effects of ABN were studied by hot plate induced-toe pain and acetic acid-induced writhing response in mice. The cutting-tail method was adopted to study the hemostasis effect of ABN. Rabbit skin wound healing experiment was used to study the effect of ABN on wound healing. RESULTS： Compared with blank group， ABN could significantly relieve auricular swelling induced by xylene and toe swelling induced by albumen （P＜0.05）. ABN also could prolong pain threshold of hot plate-inducing toe pain and reduce acetic acid-inducing writhing response in mice （P＜0.05）； it could shorten bleeding time of cutting-tail in mice （P＜0.05） and promote wound healing of rabbits. Above effects of ABN were almost similar to Yunnan Baiyao， and even better in anti-inflammation and promoting wound healing. CONCLUSIONS： ABN has a satisfactory anti-inflammatory， analgesic， hemostasis and wound healing effect. |
| 期刊： | 2018年第29卷第22期 |
| 作者： | 魏玉，张小玲，余瑾瑾，张明昊，栗俞程，沈继朵 |
| AUTHORS： | WEI Yu，ZHANG Xiaoling，YU Jinjin，ZHANG Minghao，LI Yucheng，SHEN Jiduo |
| 关键字： | 紫草；白及；纳米乳；云南白药；抗炎；镇痛；止血；促进伤口愈合；药效学 |
| KEYWORDS： | Arnebiae Radix； Bletillae Rhizoma； Nanoemulsion； Yunnan Baiyao； Anti-inflammatory； Analgesic； Hemostasis； Wound healing promotion； Pharmacodynamics |
| 阅读数： | 275 次 |
| 本月下载数： | 4 次 |
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