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基于文献计量学的国内人血白蛋白临床合理应用水平分析
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| 篇名： | 基于文献计量学的国内人血白蛋白临床合理应用水平分析 |
| TITLE： | |
| 摘要： | 目的：采用文献计量学方法对国内2001－2017年人血白蛋白的临床应用状况进行分析，总结我国人血白蛋白的临床合理应用水平，为规范其使用提供依据。方法：计算机检索中国知网、维普网、万方数据于2001年1月－2017年12月发表的国内人血白蛋白临床合理应用水平分析相关文献，对纳入文献的类型、基本情况（文献发表时间、发表区域分布、期刊杂志分布）、具体内容（共词、医院等级、使用科室及适应证、评价依据及结果、干预手段）等进行分析，总结规律并提出建议。结果：共检索出文献581篇，其中有效文献98篇，包括83篇回顾性调查和15篇干预类文献。文献发表数量在2005年之后总体呈现上升趋势，2016年最多（16篇）；文献发表区域主要集中在江苏、浙江、北京、福建等地区，98篇文献分布于50种期刊，其中刊文量前三的期刊为《中国药房》（7 篇）、《药物流行病学杂志》和《中国医院用药评价与分析》（各5篇）。共词分析结果主要有“人血白蛋白”“临床应用”“合理用药”“分析”“调查”“回顾性调查”“临床药师”“循证医学”等。病例总数为68 197 例，使用量较多的是三级医院（73家），居前四位的科室分别是重症加强护理病房（ICU）、心胸外科、普外科和消化内科；适应证中低蛋白症（17.2％）、营养支持（13.7％）仍占较大比例，但有6.4％属于无指征用药；药品说明书适应证符合率在50％以上的文献仅占27.3％，而美国医院联合会（UHC）指南用药符合率在50％以上的文献仅占8.9％。在15篇干预类文献中，干预手段包括临床药师参与、建立评估体系或模型、制订管理审批制度、进行处方点评等。结论：人血白蛋白临床应用的相关研究处于逐年递增的趋势，国内对其愈发重视，然各地区研究水平分布不均衡。我国人血白蛋白临床应用尚缺乏统一标准，合理用药水平有待提升，建议尽快制订国家指南，增加干预措施和力度，规范人血白蛋白的合理使用，避免造成资源浪费。 |
| ABSTRACT： | OBJECTIVE： To analyze the clinical application of human serum albumin in China from 2001 to 2017 by using bibliometric method， so as to summarize the level of clinical rational use of human serum albumin in China， and provide evidence to regulate use of it. METHODS： Retrieved from CNKI， VIP， Wanfang database， related literatures about clinical rational use of human serum albumin in China were collected during Jan. 2001-Dec. 2017. Type， general information （publication time， publication area distribution， journal distribution） and specific content （co-word analysis， hospital level， department， indication， evaluation evidence and results， intervention measures） of included literatures were analyzed. The regularity was summarized to put forward the suggestions. RESULTS： All of 581 literatures were included， involving 98 valid literatures， among which there were 83 retrospective investigations and 15 intervention literatures. The number of literature was in increasing tendency after 2015， the most in 2016 （16 literatures）. The publications area were mainly concentrated in Jiangsu， Zhejiang， Beijing and Fujian. Totally 98 literatures were published by 50 kinds of journals. Top 3 journals in the list of publication number were China Pharmacy （7 literatures）， Chinese Journal of Pharmacoepidemiology （5 literatures） and Evaluation and Analysis of Drug-Use in Hospitals of China （5 literatures）. Results of co-word analysis included “human serum albumin” “clinical application” “rational drug use” “analysis” “investigation” “retrospective investigation” “clinical pharmacist” “evidence-based medicine” etc. The total number of cases was 68 197 cases. The albumin was mostly common used in third grade hospitals （73 hospitals）； top 4 departments were ICU， cardiothoracic surgery department， general surgery department， and digestive disease department. Among indication， hypoalbuminemia （17.2％） and nutritional support（13.7％） still took up a significant proportion， but 6.4％ belonged to no indication. In only 27.3％ literatures， compliance rate of indications in drug package inserts was higher than 50％， while the rate was only 8.9％ with the UHC guidelines. Among 15 intervention literatures， intervention methods included the participation of clinical pharmacists， establishment of evaluation system or model， formulation of management approval system， prescription review， etc. CONCLUSIONS： Clinical application of human albumin related research has increased year by year， and more and more attention has been paid to it. But the level of research is uneven in different regions. There is no uniform standard for the application of human serum albumin in China. To improve rational drug use level， develop national guidelines should be developed as soon as possible， intervenient measures should be adopted and strengthened so as to standardize rational use of human serum albuminand avoid waste of resources. |
| 期刊： | 2018年第29卷第19期 |
| 作者： | 黄晓倩，李文惠，李长清，王宗奎，刘彬，王娅 |
| AUTHORS： | HUANG Xiaoqian，LI Wenhui，LI Changqing，WANG Zongkui，LIU Bin，WANG Ya |
| 关键字： | 人血白蛋白；临床应用；文献计量学；回顾性调查；干预；指南 |
| KEYWORDS： | Human serum albumin； Clinical application； Bibliometrics； Retrospective investigation； Intervention； Guideline |
| 阅读数： | 555 次 |
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