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康复新液治疗鼻咽癌患者放射性皮炎的临床观察
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| 篇名： | 康复新液治疗鼻咽癌患者放射性皮炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察康复新液治疗鼻咽癌患者放射性皮炎的临床疗效及安全性。方法：选取2016年2月－2017年2月昆明医科大学第三附属医院肿瘤科收治的患有放射性皮炎的鼻咽癌患者73例，按随机数字表法分为对照组（36例）和观察组（37例）。两组患者均给予甲紫溶液、复方鱼肝油氧化锌软膏外涂等常规治疗；观察组在常规治疗的基础上，将康复新液浸透纱布后，敷于患处，每日3次。两组患者的疗程均为4周。比较两组患者的临床疗效、治疗前后美国肿瘤放射治疗协作组（RTOG）皮炎分级和皮炎面积，并记录不良反应发生情况。结果：观察组患者的临床总有效率（94.6％）与对照组（97.2％）比较，差异有统计学意义（P＜0.05）。治疗前后，两组均未见RTOG Ⅳ级皮炎患者。治疗前，两组患者RTOG 0～Ⅲ级皮炎患者的比例、皮炎面积比较，差异均无统计学意义（P＞0.05）。治疗后，观察组RTOG皮炎分级情况显著改善，且0级患者的比例显著高于对照组，Ⅰ级患者的比例显著低于对照组，差异均有统计学意义（P＜0.05）；对照组患者治疗前后RTOG 0～Ⅲ级皮炎患者的比例比较，差异均无统计学意义（P＞0.05）。治疗后第2、4周，两组患者的皮炎面积均显著缩小，治疗后第4周显著小于治疗后第2周，且观察组显著小于对照组，差异均有统计学意义（P＜0.05）。两组患者在治疗期间均未见明显不良反应发生。结论：加用康复新液治疗鼻咽癌患者放射性皮炎可有效缓解皮炎症状，缩小皮炎面积，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Kangfuxin liquid in the treatment of radioactive dermatitis of nasopharyngeal carcinoma patients. METHODS： A total of 73 nasopharyngeal carcinoma patients with radioactive dermatitis in the Third Affiliated Hospital of Kunming Medical University during Feb. 2016 to Feb. 2017 were divided into control group （36 cases） and observation group （37 cases） according to random number table. Both groups received routine treatment as Methylrosanilinium chloride solution， Compound cod liver oil and zinc oxide ointment for external use. Observation group was additionally given gauze soaked with Kangfuxin liquid on affected area， 3 times a day on the basis of routine treatment. Both groups were treated for 4 weeks. Clinical efficacies of 2 groups were compared， and RTOG classification and dermatitis area were compared before and after treatment. The occurrence of ADR was recorded. RESULTS： There was statistical significance in the total response rate between observation group （94.6％） and control group （97.2％） （P＜0.05）. Before and after treatment， there were no RTOG Ⅳ patients in 2 groups. Before treatment， there was no statistical significance in the proportion of RTOG 0-Ⅲ patients or dermatitis area between 2 groups （P＞0.05）. After treatment， RTOG classification of observation group was improved significantly， the proportion of grade 0 patients was significantly higher than control group， that of gradeⅠpatients was significantly lower than control group， with statistical significance （P＜0.05）. There was no statistical significance in the proportion of RTOG 0-Ⅲ patients of control group before and after treatment （P＞0.05）. Two， four weeks after treatment， dermatitis areas of 2 groups were decreased significantly； dermatitis area 4 weeks after treatment was significantly smaller than 2 weeks after treatment； observation group was significantly smaller than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Additional use of Kangfuxin liquid in the treatment of radioactive dermatitis of nasopharyngeal carcinoma patients can effectively relieve symptoms and reduce dermatitis area with good safety. |
| 期刊： | 2018年第29卷第10期 |
| 作者： | 冯志平，宋元华，邓智勇，夏耀雄，刘超，陈富坤，杨传周 |
| AUTHORS： | FENG Zhiping，SONG Yuanhua，DENG Zhiyong，XIA Yaoxiong，LIU Chao，CHEN Fukun，YANG Chuanzhou |
| 关键字： | 鼻咽癌；放射性皮炎；康复新液；临床疗效；安全性 |
| KEYWORDS： | Nasopharyngeal carcinoma； Radioactive dermatitis； Kangfuxin liquid； Clinical efficacy； Safety |
| 阅读数： | 419 次 |
| 本月下载数： | 29 次 |
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