注射用前列地尔干乳剂联合丁苯酞软胶囊对重症缺血性脑卒中患者神经功能、炎症因子及凝血功能的影响-中国药房

注射用前列地尔干乳剂联合丁苯酞软胶囊对重症缺血性脑卒中患者神经功能、炎症因子及凝血功能的影响

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篇名：	注射用前列地尔干乳剂联合丁苯酞软胶囊对重症缺血性脑卒中患者神经功能、炎症因子及凝血功能的影响
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摘要：	目的：观察注射用前列地尔干乳剂联合丁苯酞软胶囊对重症缺血性脑卒中患者神经功能、炎症因子及凝血功能的影响。方法：选取2015年6月－2017年10月于我院就诊的重症缺血性脑卒中患者66例，按随机数字表法分为对照组和观察组，各33例。对照组患者在常规治疗的基础上给予丁苯酞软胶囊0.2 g/次，空腹口服，tid；观察组患者在对照组的基础上加用注射用前列地尔干乳剂10 μg加至0.9％氯化钠注射液10 mL中缓慢静注或入小壶缓慢静滴，qd。两组患者均连续治疗14 d。观察两组患者治疗前后美国国立卫生研究院卒中量表（NIHSS）和Barthel指数评分、血清炎症因子[C反应蛋白（CRP）、降钙素原（PCT）]和凝血功能指标[D-二聚体（D-D）、凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）]水平，并记录不良反应发生情况。结果：治疗前，两组患者上述指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者NIHSS评分，CRP、PCT、D-D、FIB水平均显著降低，Barthel指数评分显著升高，TT、PT、APTT均显著延长，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：注射用前列地尔干乳剂联合丁苯酞软胶囊可有效改善重症缺血性脑卒中患者的神经功能及凝血功能，降低炎症因子水平，且安全性较高。
ABSTRACT：	OBJECTIVE： To observe the effects of Alprostadil dried emulsion for injection combined with Butylphthalide soft capsules on nerve function， inflammatory factor and coagulation function of patients with severe ischemic stroke. METHODS： A total of 66 patients with severe ischemic stroke selected from our hospital during Jun. 2015-Oct. 2017 were divided into control group and observation group according to random number table， with 33 cases in each group. On the basis of routine treatment， control group was additionally given Butyphthalide soft capsules 0.2 g/time， orally at fasting state， tid. On the basis of control group， observation group was additionally given Alprostadil dried emulsion for injection 10 μg added into 0.9％ Sodium chloride injection 10 mL， via slow infusion or slow dripping with pipkin， qd. Both groups were treated for 14 days. NIHSS and Barthel index scores， the levels of serum inflammatory factors （CRP， PCT） and coagulation function indexes （D-D， TT， PT， APTT， FIB） were observed in 2 groups before and after treatment， and the occurrence of ADR was also recorded. RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， NIHSS scores， the levels of CRP， PCT， D-D and FIB in 2 groups were deceased significantly， while Barthel index scores were increased significantly， TT， PT， APTT were prolonged significantly； observation group was significantly better than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Alprostadil dried emulsion for injection combined with Butylphthalide soft capsules can effectively improve nerve function and coagulation function of patients with severe ischemic stroke， and reduce the levels of inflammatory factor with good safety.
期刊：	2018年第29卷第8期
作者：	李洁，覃铁和，王首红，温剑艺，郭伟新，王中华，廖小龙
AUTHORS：	LI Jie，QIN Tiehe，WANG Shouhong，WEN Jianyi，GUO Weixin，WANG Zhonghua，LIAO Xiaolong
关键字：	重症缺血性脑卒中；注射用前列地尔干乳剂；丁苯酞软胶囊；神经功能；炎症因子；凝血功能
KEYWORDS：	Severe ischemic stroke； Alprostadil dried emulsion for injection； Butylphthalide soft capsules； Nerve function； Inflammatory factor； Coagulation function
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