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原子吸收分光光度法测定藏药二十五味珊瑚丸中5种重金属含量
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| 篇名： | 原子吸收分光光度法测定藏药二十五味珊瑚丸中5种重金属含量 |
| TITLE： | |
| 摘要： | 目的：建立测定藏药二十五味珊瑚丸中5种重金属含量的方法，并考察西藏不同地区5个厂家生产的该药品中重金属含量情况。方法：以浓硝酸-高氯酸（4 ∶ 1，V/V）消解二十五味珊瑚丸样品，采用火焰原子吸收分光光度法测定其中铜（Cu）、铅（Pb）、镉（Cd）3种重金属元素的含量，氢化物发生原子吸收分光光度法测定其中砷（As）、汞（Hg）2种重金属元素的含量。结果：5种重金属元素含量检测在相应质量浓度范围内线性关系均良好（r均≥0.999 1）；Cu、Pb、Cd元素的检测限分别为0.001 6、0.041 2、0.036 3 mg/L，定量限分别为0.005 3、0.137 3、0.121 0 mg/L；As、Hg元素的检测限分别为0.325 7、0.692 3 μg/L，定量限分别为1.085 7、2.307 7 μg/L；精密度试验的RSD均≤5.54％（n＝6）；稳定性试验的RSD均≤3.79％；重复性试验的RSD均≤3.72％；平均加样回收率为91.34％～110.11％，RSD为0.66％～6.80％（n＝6）。含量测定结果显示，5个厂家的样品中Cu含量皆未超标，但 Cd、Hg含量均超标；其中还有4个厂家样品中Pb含量超标，2个厂家样品中As含量超标。结论：建立的含量测定方法的准确度、灵敏度较高，且稳定性、重复性较好，适用于二十五味珊瑚丸中5种重金属含量的测定；5个厂家生产样品均在一定程度上存在重金属超标问题。 |
| ABSTRACT： | OBJECTIVE： To establish a method for the contents determination of 5 heavy metals in Ershiwuwei shanhu pills，and to investigate the contents of heavy metals in Ershiwuwei shanhu pills produced by 5 manufacturers from different districts of Tibet. METHODS： Ershiwuwei shanhu pills were digested by HNO3-HClO4 （4 ∶ 1，V/V）. The contents of 3 heavy metals as Cu， Pb， Cd in samples were measured by flame atomic absorption spectrometry （FAAS）. The contents of 2 heavy metals as As，Hg in samples were measured by hydride generation atomic absorption spectrometry （HG-AAS）. RESULTS： 5 kinds of heavy metals have good linear relationship in the corresponding mass concentration range （all r≥0.999 1）. The limits of detection of Cu， Pb， Cd were 0.001 6， 0.041 2， 0.036 3 mg/L， and the limits of quantitation were 0.005 3， 0.137 3， 0.121 0 mg/L； the limits of detection of As， Hg were 0.325 7， 0.692 3 μg/L， and the limits of quantitation were 1.085 7， 2.307 7 μg/L. RSDs of precision tests were ≤5.54％（n＝6）； RSDs of stability tests were all≤3.79％； RSDs of reproducibility tests were ≤3.72％. The average recovery rates were 91.34％-110.11％ （RSDs were 0.66％-6.80％，n＝6）. Results of contents determination showed that the contents of Cu in samples from 5 manufacturers were not out of limits， but the contents of Cd and Hg were all out of limits; the contents of Pb in samples from 4 manufacturers were out of limits， and the contents of As in samples from 2 manufacturers were out of limits. CONCLUSIONS： The established method has good accuracy， sensitivity， stability and reproducibility， and it is suitable for contents determination of 5 heavy metals in Ershiwuwei shanhu pills. To some extent，there is a problem of excessive heavy metals in samples from 5 manufacturers. |
| 期刊： | 2018年第29卷第7期 |
| 作者： | 刘兰，张勇仓，钟铧，次仁久米，王聚乐 |
| AUTHORS： | LIU Lan，ZHANG Yongcang，ZHONG Hua，Cirenjiumi，WANG Jule |
| 关键字： | 火焰原子吸收分光光度法；氢化物发生原子吸收分光光度法；二十五味珊瑚丸；重金属；含量测定 |
| KEYWORDS： | Flame atomic absorption spectrometry； Hydride generation atomic absorption spectrometry； Ershiwuwei shanhu pills； Heavy metals； Content determination |
| 阅读数： | 523 次 |
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