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3种用药方案治疗甲状腺功能亢进的药物经济学评价
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| 篇名： | 3种用药方案治疗甲状腺功能亢进的药物经济学评价 |
| TITLE： | |
| 摘要： | 目的：评价3种用药方案治疗甲状腺功能亢进的经济性。方法：收集我院2016年全年诊疗的564例甲状腺功能亢进门诊患者的病历资料，按照用药方案分成A组（185例）、B组（191例）和C组（188例）。A组患者口服甲巯咪唑片2～4片，每天1次，视病情逐渐减量至0.5～2片；B组患者口服甲巯咪唑片（用法用量同A组）+抑亢丸6 g，每天2次；C组患者口服甲巯咪唑片（用法用量同A组）+夏枯草片6片，每天2次。3组患者疗程均为10个月。观察3组患者临床疗效、不良反应发生情况和复发情况，并运用药物经济学的成本-效果分析法对3种治疗方案进行经济学评价。结果：A、B、C组的总有效率分别为94.06％、95.29％、95.75％ ，总不良反应发生率分别为11.36％、10.48％、10.11％，差异均无统计学意义（P＞0.05），3组患者均未出现复发情况。3组患者人均成本分别为633.80、3 548.89、3 596.00元，A组成本最低。敏感度分析结果显示亦为A组成本最低。结论：3种用药方案治疗甲状腺功能亢进的疗效与安全性均较好，其中甲巯咪唑单用方案具有较高的经济性。 |
| ABSTRACT： | OBJECTIVE： To evaluate the economical efficiency of 3 therapeutic regimens for hyperthyroidism. METHODS： Medical records of 564 hyperthyroid outpatients were selected from our hospital in 2016， and they were divided into group A （185 cases）， group B（191 cases） and group C（188 cases） according to drug use. Group A received Thiamazole tablets 2-4 tablet，once asthecondition gradually reduce th amount to 0.5-2 tablets orally； group B received Thiamazole tablets （cusage and dosage are the same as group A）+Yikang pills 6 g，bid orally； group C received Thiamazole tablets （cusage and dosage are the same as group A）+Xiakucao tablets 6 tablets，bid orally. The treatment courses of 3 groups lasted for 10 months. Clinical efficacy the occurrence of ADR and recurrence were observed in 3 groups.The pharmacoeconomic cost-effectiveness analysis was adopted for the economic evaluation of 3 therapeutic regimens. RESULTS： The tolal response rates of group A， B， C were 94.06％， 95.29％， 95.75％， respectively； total incidence of ADR were 11.36％， 10.48％， 10.11％； there was no statistical significance （P＞0.05）. No recurrence occurred in the 3 groups. The average cost of 3 groups were 633.80， 3 548.89， 3 596.00 yuan， respectively. The cost of group A was the lowest. The results of sensitivity analysis were also that the cost of group A was the lowest. CONCLUSIONS： 3 therapeutic regimens show good therapeutic efficacy and safety for hyperthyroidism， among which thiamazole alone has relatively higher pharmacoeconomic significance. |
| 期刊： | 2018年第29卷第3期 |
| 作者： | 唐哲，韦韡，曹步清 |
| AUTHORS： | TANG Zhe，WEI Wei，CAO Buqing |
| 关键字： | 药物经济学；甲状腺功能亢进；甲巯咪唑片；抑亢丸；夏枯草片；最小成本分析 |
| KEYWORDS： | Pharmacoeconomics； Hyperthyroidism； Thiamazole tablets； Yikang pills； Xiakucao tablets； Cost minimization analysis |
| 阅读数： | 267 次 |
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