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丹参川芎嗪注射液联合高压氧对急性脊髓损伤早期并发症的预防作用
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| 篇名： | 丹参川芎嗪注射液联合高压氧对急性脊髓损伤早期并发症的预防作用 |
| TITLE： | |
| 摘要： | 目的：探讨丹参川芎嗪注射液联合高压氧对急性脊髓损伤早期并发症的预防作用。方法：按随机数字表法将89例急性脊髓损伤患者分为对照组（n＝44）和联合组（n＝45）两组。对照组予以常规对症治疗联合高压氧疗法；联合组在对照组治疗基础上给予丹参川芎嗪注射液10 mL加入250 mL 0.9％氯化钠注射液中静脉滴注，bid。两组患者均治疗2周。比较两组患者治疗前后脊柱功能恢复指标（Botsford、FIM评分）、凝血指标[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）]、血液流变学指标（全血高切黏度、血浆黏度、红细胞聚集指数）及炎症指标[D-二聚体（D-D）、C反应蛋白（CRP）]；随访1个月，比较两组患者深静脉血栓、肺动脉栓塞等早期并发症发生率。结果：对照组中途脱落2例，联合组中途脱落3例，两组各有42例患者入组。治疗前，两组患者各项指标比较，差异均无统计学意义（P＞0.05）。治疗2周后，两组患者Botsford、FIM评分均较治疗前显著提升，PT、APTT均较治疗前显著增加，全血高切黏度、血浆黏度、红细胞聚集指数及D-D、CRP水平均较治疗前显著降低，且联合组各指标均显著优于对照组，差异均有统计学意义（P＜0.05或P＜0.01）。联合组患者早期并发症发生率为16.7％，显著低于对照组的35.7％，差异有统计学意义（P＜0.05）。结论：将丹参川芎嗪注射液联合高压氧应用于急性脊髓损伤患者外科手术后，可有效降低其深静脉血栓、肺动脉栓塞等早期并发症发生风险，对缓解炎症反应、促进血液微循环、改善患者预后等有积极作用。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Danshen chuanxiongqin injection combined with hyperbaric oxygen on the prevention of early complications in patients with acute spinal cord injury （ASCI）. METHODS： A total of 89 ASCI patients were divided into control group （n＝44） and combination group （n＝45） according to random number table. Control group received routine symptomatic treatment combined with hyperbaric oxygen therapy. Combination group was additionally given Danshen chuanxiongqin intravenous injection 10 mL added into 250 mL 0.9％ Sodium chloride injection intravenously，bid，on the basis of control group. Both group was treated for 2 weeks. The changes of spinal cord function recovery index （Botsford score， FIM score）， coagulation indexes [prothrombin time （PT）， activated partial thromboplastin time （APTT）]， hemodynamic indexes （high-shear blood viscosity， plasma viscosity， erythrocyte aggregation indexes） and inflammatory indexes [D-dimer （D-D）， C reactive protein （CRP）] were compared between 2 groups before and after treatment. After 1 month of follow-up， the incidence of early complications as deep venous thrombosis and pulmonary embolism were compared between 2 groups. RESULTS： Two cases lost in control group and three cases lost in combination group； 42 cases were included in each group. Before treatment，there was no statistical significance between these indexes between 2 groups （P＞0.05）. After 2 weeks of treatment， Botsford score， FIM score， PT and APTT of 2 groups were enhanced significantly compared to before treatment； high-shear blood viscosity， plasma viscosity， erythrocyte aggregation indexes， D-D， CRP level were decreased significantly compared to before treatment； each index of combination group was significantly better than those of control group， with statistical significance （P＜0.05 or P＜0.01）. The incidence of early complications in combination group was 16.7％， which was significantly lower than 35.7％ in control group， with statistical significance （P＜0.05）. CONCLUSIONS： The application of Danshen chuanxiongqin injection combined with hyperbaric oxygen in the clinical treatment of ASCI can effectively reduce the risk of deep venous thrombosis， pulmonary embolism and other early complications. It has positive effects on alleviating inflammatory reactions， promoting blood microcirculation and improving prognosis of patients. |
| 期刊： | 2018年第29卷第2期 |
| 作者： | 俞勇，陈明，彭爱明，刘辉，阮翔 |
| AUTHORS： | YU Yong，CHEN Ming，PENG Aiming，LIU Hui，RUAN Xiang |
| 关键字： | 丹参川芎嗪注射液；高压氧；急性脊髓损伤；早期并发症；预防 |
| KEYWORDS： | Danshen chuanxiongqin injection； Hyperbaric oxygen； Acute spinal cord injury； Early complication； Prevention |
| 阅读数： | 935 次 |
| 本月下载数： | 2 次 |
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