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治疗气虚血瘀证中成药的组方规律分析
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| 篇名： | 治疗气虚血瘀证中成药的组方规律分析 |
| TITLE： | |
| 摘要： | 目的：了解治疗气虚血瘀证中成药的组方规律，为气虚血瘀证候诊断标准规范的研究及相关证候类中药新药研究提供参考。方法：收集2015年版《中国药典》和1993年版《中药成方制剂》中用于治疗气虚血瘀证的中成药，并利用中医传承辅助系统（V2.5）软件进行组方规律与症状关联规律分析。结果：171个症状中，胸闷、气短、胸痛、乏力、心悸是常见症状，而聚类得到3类症状组合，即胸闷-气短-胸痛-心悸-怔忡-脉结代、口眼歪斜-手足麻木-半身不遂-舌强-拘挛、月经量少-月经不调-腹有癥块-经行腹痛。131首中成药包括304味中药，使用频率前5位的为黄芪、丹参、当归、川芎和人参；高频药物组合有黄芪-当归、川芎-当归、丹参-黄芪、川芎-黄芪和川芎-丹参，核心组合是黄芪-当归-川芎-丹参-人参-红花-三七；得到治疗气虚血瘀证的新方1个（人参-赤芍-冰片-天麻-人工麝香-肉豆蔻）。结论：气虚血瘀证既具有大多数疾病共有的症状，如胸闷、胸痛、气短等，又具有各类疾病独有的特征性症状。益气活血法是气虚血瘀证的基本治法，临床上应根据正邪盛衰不同，注重“以通为补，通补结合”，并合理配以理气法、补血法或芳香温通法，对气虚血瘀证的治疗具有一定的临床意义。 |
| ABSTRACT： | OBJECTIVE： To investigate the regularity of Chinese patent medicine prescriptions for Qi deficiency and blood stasis syndrome （QDBSS）， and to provide reference for studying QDBSS diagnosis standard and new TCM for related symptoms. METHODS： Chinese patent medicine for QDBSS were collected from Chinese Pharmacopoeia （2015 edition） and Chinese Materia Medica Preparation （1993 version）. The regularity of Chinese patent medicine prescriptions and symptom association rule were analyzed by using TCM inheritance auxiliary system （V2.5）. RESULTS： Among the 171 symptoms， chest tightness， shortness of breath， chest pain， fatigue and palpitation were common symptoms， and three groups of symptoms were included as chest tightness-shortness of breath-chest pain-palpitation-irregularly pulse； mouth and eye deviation-numbness of hands and feet-hemiplegia-stiff tongue-spasm； hypomenorrhea-irregular menstruation-abdominal mass-dysmenorrheal. One hundred and thirty-one Chinese patent medicines included 304 ingredients， top 5 in the list of frequency were Astragalus membranaceus， Salvia militiorrhiza， Angelica sinensis， Ligusticum chuanxiong， Panax ginseng. A. membranaceus- A. sinensis， L. chuanxiong-A. sinensis， S. militiorrhiza-A. membranaceus， L. chuanxiong- A. membranaceus and L. chuanxiong-S. militiorrhiza were frequently used herbal combinations. A. membranaceus-A. sinensis-L. chuanxiong-S. militiorrhiza-P. ginseng-Carthamus tinctorius-Panax notoginseng was the core combination. A new prescription for QDBSS was formed （P. ginseng-Radix Paeoniae Rubra-borneol-Gastrodia elata-artificial moschus-Myristica fragrans）. CONCLUSIONS： QDBSS has common symptoms which exist in many kinds of diseases， such as chest tightness， chest pain and shortness of breath； it also has the unique symptoms among various diseases. Invigorating Qi and promoting blood circulation is the basic treatment for the QDBSS. It is of significance to pay attention to “supplement by passing， combination of pass and supplement” and combine regulating Qi-flowing method with enriching blood method or aromatic warming method for QDBSS therapy according to the difference of Zhengxie shengshuai. |
| 期刊： | 2017年第28卷第35期 |
| 作者： | 何浩强，高嘉良，陈光，刘超，王阶 |
| AUTHORS： | HE Haoqiang，GAO Jialiang，CHEN Guang，LIU Chao，WANG Jie |
| 关键字： | 气虚血瘀证；中成药；中国药典；中药成方制剂；组方规律 |
| KEYWORDS： | Qi deficiency and blood stasis syndrome； Chinese patent medicine； Chinese Pharmacopoeia； Chinese Materia Medica Preparation； Regularity of prescriptions |
| 阅读数： | 701 次 |
| 本月下载数： | 6 次 |
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