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热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效分析
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| 篇名： | 热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效分析 |
| TITLE： | |
| 摘要： | 目的：观察热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效和安全性。方法：回顾性分析120例中晚期肺腺癌患者资料，按治疗方案不同分为对照组（60例）和观察组（60例）。对照组患者给予注射用培美曲塞二钠500 mg/m2，静脉滴注，d1+注射用顺铂75 mg/m2，静脉滴注，d2～4（分3 d使用）。21 d为1个周期，至少化疗2个周期。观察组患者在对照组化疗的基础上行热疗每月1次，共2～4次。观察两组患者的临床疗效，生活质量改善情况及毒副反应发生情况。结果：两组患者至少接受2个周期治疗。观察组患者总有效率（63.3％）显著高于对照组（36.7％），生活质量改善率（60.0％）显著高于对照组（33.3％），差异均有统计学意义（P＜0.05）。两组患者Ⅲ～Ⅳ度肝肾功能损害、骨髓抑制、消化道反应发生率比较，差异均无统计学意义（P＞0.05）。结论：热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效显著，可提高生存质量，且未增加严重毒副反应的发生率。 |
| ABSTRACT： | OBJECTIVE: To observe therapeutic efficacy and safety of hyperthermia combined with pemetrexed and cisplatin for medium and advanced lung adenocarcinoma. METHODS： Medical information of 120 patients with medium and advanced lung adenocarcinoma were analyzed retrospectively. They were divided into control group （60 cases） and observation group （60 cases） according to therapy method. Control group was given Pemetrexed disodium for injection 500 mg/m2 intravenously， d1+Cisplatin for injection 75 mg/m2 intravenously， d2-4. A treatment course lasted for 21 d， and both received 2 courses of treatment at least. Observation group was additionally given hyperthermia， once a month， 2-4 times in total， on the basis of control group. Clinical efficacies， the improvement of life quality and the occurrence of toxic reaction were observed in 2 groups. RESULTS： Both groups received 2 courses of treatment at least. Total response rate of observation group （63.3％） was significantly higher than that of control group （36.7％）， and the improvement rate of life quality （60.0％） was significantly higher than control group （33.3％）， with statistical significance （P＜0.05）. There was no statistical significance in Ⅲ-Ⅳ degree liver and renal function injury， myelosuppression or the incidence of gastrointestinal tract between 2 groups （P＞0.05）. CONCLUSIONS: Hyperthermia combined with pemetrexed and cisplatin shows significant therapeutic efficacy for medium and advanced lung adenocarcinoma and improves survival quality without increasing the occurrence of toxic reaction. |
| 期刊： | 2017年第28卷第33期 |
| 作者： | 郑国宝，张建国 |
| AUTHORS： | ZHENG Guobao，ZHANG Jianguo |
| 关键字： | 热疗；培美曲塞；顺铂；中晚期肺腺癌；疗效；安全性 |
| KEYWORDS： | Hyperthermia； Pemetrexed； Cisplatin； Medium and advanced lung adenocarcinoma； Therapeutic efficacy； Safety |
| 阅读数： | 252 次 |
| 本月下载数： | 2 次 |
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