1例肝硬化合并上消化道出血患者肠外营养支持的药学监护
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篇名: 1例肝硬化合并上消化道出血患者肠外营养支持的药学监护
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摘要: 目的:探讨临床营养药师在肝硬化合并上消化道出血患者肠外营养支持中的作用。方法:临床营养药师参与1例肝硬化合并上消化道出血患者的肠外营养支持会诊,结合患者的病因、肝功能状况、并发症、药物对肝功能的影响等,通过两次会诊,建议患者的营养液中不再加入胰岛素,将20%脂肪乳注射液(C14-24)250 mL调整为20%中/长链脂肪乳注射液(C8-24)250 mL、复方氨基酸注射液(18AA-Ⅴ)350 mL调整为六合氨基酸注射液(6AA)350 mL、葡萄糖酸钙注射液1.0 g调整为0.7 g,并增加甘油磷酸钠注射液10 mL、注射用丙氨酰谷氨酰胺10 g,滴注速度由2 mL/min降至1.5 mL/min,葡萄糖注射液(100 mL ∶ 50 g)由300 mL增加至350 mL,同时检测血糖。结果:医师采纳了临床营养药师的建议,患者病情稳定,血糖控制平稳,直至患者上消化道出血症状得到控制,饮食恢复正常,未再出现低血糖症状。结论:临床营养药师参与患者的肠外营养支持等相关药学监护,对改善患者的营养状况及预后具有积极的作用。
ABSTRACT: OBJECTIVE: To investigate the role of clinical pharmacists on parenteral nutrition support for liver cirrhosis patients with gastrointestinal bleeding. METHODS: Clinical pharmacists participated in parenteral nutrition support consultation for a liver cirrhosis patient with gastrointestinal bleeding. Based on etiology, liver function, complications and the effects of drugs on liver function, through two consultation, it was suggested to no longer add insulin into the patient’s nutrient solution, adjust 20% Fat emulsion injection(C14-24)250 mL to 20% Medium-chain and long-chain fat emulsion injection (C8-24) 250 mL, adjust Compound amino acid injection(18AA-Ⅴ)350 mL to 6 Amino acid injection(6AA)350 mL, adjust Calcium gluconate injection 1.0 g to 0.7g. Sodium glycerophosphate injection 10 mL and Alanyl glutamine for injection 10 g were added, decreasing dripping speed from 2 mL/min to 1.5 mL/min, increase Glucose injection (100 mL ∶ 50 g) from 300 mL to 350 mL. Blood glucose was also detected. RESULTS: Physicians adopted the suggestion of clinical pharmacists. The patient’s condition and blood glucose control would keep stable till gastrointestinal bleeding was controlled, the diet returned to normal and none of above symptoms occurred again. CONCLUSIONS: The participation of clinical nutrition pharmacists in pharmaceutical care as parenteral nutrition support plays active role on the improvement of patients’ nutritive condition and clinical prognosis improvement.
期刊: 2017年第28卷第32期
作者: 李晓明,蔺洁,李尧,史英钦
AUTHORS: LI Xiaoming,LIN Jie,LI Yao,SHI Yingqin
关键字: 肝硬化;上消化道出血;肠外营养;药学监护;临床营养药师
KEYWORDS: Liver cirrhosis; Gastrointestinal bleeding; Parenteral nutrition; Pharmaceutical care; Clinical nutrition pharmacist
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