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复方益母草膏联合屈螺酮炔雌醇片对药物流产后患者血清孕酮及Th1/Th2细胞因子的影响
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| 篇名： | 复方益母草膏联合屈螺酮炔雌醇片对药物流产后患者血清孕酮及Th1/Th2细胞因子的影响 |
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| 摘要： | 目的：探讨复方益母草膏联合屈螺酮炔雌醇片对药物流产后患者血清孕酮、辅助性T细胞（Th）1/Th2细胞因子的影响。方法：选取2013年3月－2015年7月我院产科门诊行药物流产的228例患者作为研究对象，按照随机数字表法将患者分为对照组（109例）和观察组（119例）。对照组患者在药物流产致胎囊排除后给予头孢呋辛酯片0.25 g，po，bid，连续服用6 d抗感染+屈螺酮炔雌醇片1片，po，qd，连续服用21 d为1个周期，间隔8 d后开始第2个服药周期，共给药3个周期。观察组患者在对照组基础上加用复方益母草膏10 g，po，bid，7 d为1个疗程，连续给药2个疗程。观察两组患者血清孕酮、Th1细胞因子[肿瘤坏死因子α（TNF-α）、γ干扰素（IFN-γ）、白细胞介素2（IL-2）]和Th2细胞因子（IL-4、IL-6、IL-10）水平，并记录不良反应发生情况。结果：治疗前，两组患者血清孕酮、Th1/Th2细胞因子水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者血清孕酮、TNF-α、IL-2和IL-6水平均显著降低，且观察组显著低于对照组；两组患者IL-4、IL-10水平均显著升高，且观察组显著高于对照组，差异均有统计学意义（P＜0.05）。治疗后，两组患者IFN-γ水平均显著降低，但组间比较差异无统计学意义（P＞0.05）。两组患者在治疗过程中均未见明显的不良反应发生。结论：复方益母草膏联合屈螺酮炔雌醇片可调节药物流产后患者机体的免疫功能，维持Th1/Th2细胞因子的动态平衡，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Compound Leonurus artemisia ointment combined with Drospirenone and ethinylestradiol tablets on serum progesterone and T helper （Th） 1/Th2 cytokine after medical abortion. METHODS： A total of 228 patients underwent medical abortion selected from obstetrical outpatient of our hospital during our hospital during Mar. 2013 to Jul. 2015 as research object were divided into control group （109 cases） and observation group （119 cases） according to random number table. Control group was given Cefuroxime axetil tablets 0.25 g， po， bid， for consecutive 6 d for anti-infective treatment+ Drospirenone and ethinylestradiol tablets one tablet， po， qd， 21 d as a treatment course， 8 d later receiving second course， 3 courses in total after fetal sac exclusion. Observation group was additionally given Compound L. artemisia ointment 10 g， po， bid，7 d as a treatment course， 2 courses in total on the basis of control group. The levels of serum progesterone and Th1（TNF-α， IFN-γ， IL-2）/Th2 cytokine （IL-4， IL-6， IL-10） were observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in serum progesterone or Th1/Th2 cytokine levels between 2 groups （P＞0.05）. After treatment， serum progesterone， TNF-α， IL-2 and IL-6 levels of 2 groups were decreased significantly， and above indexes of observation group were significantly lower than those of control group. The levels of IL-4 and IL-10 in 2 groups were increased significantly， and above indexes of observation group were significantly higher than control group， with statistical significance （P＜0.05）. After treatment， IFN-γ levels of 2 groups were decreased significantly， but there was no statistical significance between 2 groups （P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Compound L. artemisia ointment combined with Drospirenone and ethinylestradiol tablets can regulate immune function of patients after medical abortion， and promote dynamic balance of Th1/Th2 cytokines with good safety. |
| 期刊： | 2017年第28卷第32期 |
| 作者： | 李玉霞，刘丽平，周燕 |
| AUTHORS： | LI Yuxia，LIU Liping，ZHOU Yan |
| 关键字： | 复方益母草膏；屈螺酮炔雌醇片；药物流产；Th1细胞因子；Th2细胞因子；孕酮 |
| KEYWORDS： | Compound Leonurus artemisia； Drospirenone and ethinylestradiol tablets； Medical abortion； Th1 cytokine； Th2 cytokine； Progesterone |
| 阅读数： | 330 次 |
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