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缬沙坦对老年高血压伴阵发性房颤患者相关指标的影响
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| 篇名： | 缬沙坦对老年高血压伴阵发性房颤患者相关指标的影响 |
| TITLE： | |
| 摘要： | 目的：探讨缬沙坦对老年高血压伴阵发性房颤患者相关指标的影响。方法：128例老年高血压伴阵发性房颤患者随机分为观察组和对照组，每组64例。对照组患者给予苯磺酸氨氯地平片5～10 mg/d，每日1次+氢氯噻嗪片12.5 mg/d，每日1次，清晨口服；观察组患者在对照组治疗基础上加用缬沙坦胶囊80～160 mg/d，每日1次，清晨口服。两组疗程均为12周。观察并比较两组患者治疗前后超敏C反应蛋白（Hs-CRP）、白细胞介素6（IL-6）、血压水平和左室射血分数（LVEF）、左心房内径（LAD）、P波最大时限（Pmax）、P波离散度（Pd）以及不良反应发生情况。结果：治疗前，两组患者上述各项指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者Hs-CRP、IL-6水平和LAD均显著低于同组治疗前，且观察组Hs-CRP和IL-6水平显著低于对照组，但LAD显著高于对照组；LVEF显著高于同组治疗前，但观察组显著低于对照组，差异均有统计学意义（P＜0.05）；血压水平均显著低于同组治疗前（P＜0.05），但组间比较差异无统计学意义（P＞0.05）。观察组患者Pmax和Pd均显著低于同组治疗前，且显著低于同期对照组（P＜0.05），而对照组患者Pmax和Pd治疗前后比较，差异均无统计学意义（P＞0.05）。治疗期间两组患者均未见明显不良反应发生。结论：缬沙坦治疗老年高血压伴阵发性房颤可以显著改善患者血清炎症因子水平和心脏功能相关指标，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of valsartan on related indexes of elderly patients with hypertension with paroxysmal atrial fibrillation. METHODS： A total of 128 patients with hypertension with paroxysmal atrial fibrillation were randomly divided into observation group and control group， with 64 cases in each group. Control group was given Amlodipine tablets 5-10 mg/d， once a day+Hydrochlorothiazide tablets 12.5 mg/d，once a day，orally in the morning. Observation group was additionally given Valsartan capsule 80-160 mg/d orally， once a day， in the morning. Both groups were treated for 12 weeks. The levels of Hs-CRP， IL-6 and blood pressure， LVEF， LAD， maximum P wave duration （Pmax）， P wave dispersion （Pd） before and after treatment， the occurrence of ADR were observed and compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in above indexes （P＞0.05）. After treatment， Hs-CRP，IL-6 levels and LAD of 2 groups were significantly lower than before， and Hs-CRP， IL-6 levels in the observation group was significantly lower than the control group while LAD was higher than the control groups； LVEF was significantly higher than before， but the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. After treatment， SBP and DBP of 2 groups were significantly lower than before （P＜0.05）， but there was no statistical significance between 2 groups （P＞0.05）. Pmax and Pd in the observation group were significantly lower than before，and lower than the control group at the same time（P＜0.05）， while there were no significantly of Pmax and Pd in the control group before and after treatment（P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： For elderly patients with hypertension with paroxysmal atrial fibrillation， valsartan shows good hypotensive effect and effectively improves serum inflammatory factor levels and cardiac function related indexes. |
| 期刊： | 2017年第28卷第30期 |
| 作者： | 徐珑嫣，王士兵 |
| AUTHORS： | XU Longyan，WANG Shibing |
| 关键字： | 阵发性房颤；老年；高血压；缬沙坦；炎症因子；心脏 |
| KEYWORDS： | Paroxysmal atrial fibrillation； Elderly； Hypertension； Valsartan； Inflammatory factor； Heart |
| 阅读数： | 253 次 |
| 本月下载数： | 2 次 |
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