红花黄色素治疗老年糖尿病肾病合并急性心肌梗死患者的临床观察
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篇名: 红花黄色素治疗老年糖尿病肾病合并急性心肌梗死患者的临床观察
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摘要: 目的:观察红花黄色素治疗老年糖尿病肾病合并急性心肌梗死的临床疗效及安全性。方法:选取我院 2013年1月-2015年6月收治的老年糖尿病肾病合并急性心肌梗死患者102 例作为研究对象,按照随机数字表法分为观察组(52例)和对照组(50例)。对照组患者给予抗凝,调脂,控制血糖、血压等常规治疗;观察组患者在对照组基础上加用注射用红花黄色素150 mg加入0.9%氯化钠注射液250 mL中,ivgtt,qd。两组患者均治疗2周。观察两组患者临床疗效,比较两组患者治疗前后肾功能指标[24小时微量蛋白定量(UMA)、血肌酐(Scr) 、尿素氮(BUN)、血清总胆固醇(TC)、血清三酰甘油(TG)]、心功能指标[心脏射血分数(EF)、每搏输出量(SV)、心排出量(CO)、心脏指数(CI)]、炎症因子[C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]和血液流变学指标(全血高切黏度、全血低切黏度、血细胞比容、纤维蛋白原、血小板凝聚率)。记录两组患者不良反应发生情况。结果:观察组患者的总有效率为96.15%,显著高于对照组的88.00%,差异有统计学意义(P<0.05)。治疗前,两组患者肾功能指标、心功能指标、炎症因子、血液流变学指标比较,差异均无统计学意义(P>0.05);治疗后,两组患者肾功能指标、炎症因子、血液流变学指标显著降低,心功能指标显著升高,且治疗组患者上述指标均显著优于对照组,差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:红花黄色素治疗老年糖尿病肾病合并急性心肌梗死患者疗效显著,能明显改善患者心肾功能,降低炎症因子水平,改善血液流变学指标,且安全性较高。
ABSTRACT: OBJECTIVE: To observe clinical efficacy and safety of safflower yellow pigment in the treatment of elderly patients with diabetic nephropathy complicated with acute myocardial infarction. METHODS: A total of 102 elderly patients with diabetic nephropathy complicated with acute myocardial infarction were selected from our hospital during Jan. 2013-Jun. 2015, and then divided into observation group (52 cases) and control group (50 cases) according to random number table. Control group was given routine treatment as anticoagulation, regulating blood lipid, controlling blood glucose and blood pressure. Observation group was additionally given Safflower yellow pigment for injection 150 mg added into 0.9% Sodium chloride injection 250 mL, ivgtt,qd, on the basis of control group. Both groups received treatment for 2 weeks. Clinical efficacies of 2 groups were observed. Renal function indexes (UMA, Scr, BUN, TC, TG), cardiac function indexes (EF, SV, CO, CI), inflammatory factors (CRP, IL-6, TNF-α) and hemorheological indexes (whole blood high-shear viscosity, whole blood low-shear viscosity, hematocrit, fibrinogen and platelet aggregation rate) were compared between 2 groups before and after treatment. The occurrence of ADR was recorded in 2 groups. RESULTS: Total response rate of observation group was 96.15%, which was significantly higher than 88.00% of control group, with statistical significance (P<0.05). Before treatment, there was no statistical significance in renal function indexes, cardiac function indexes, inflammatory factors or hemorheological indexes between 2 groups (P>0.05). After treatment, renal function indexes, inflammatory factors and hemorheological indexes of 2 groups were decreased significantly, while cardiac function indexes were increased significantly; above indicators of the observation group was significantly better than control group, with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS: Safflower yellow pigment shows significant therapeutic efficacy for elderly patients with diabetic nephropathy complicated with acute myocardial infarction, can significantly improve renal function and cardiac function, decrease inflammatory factor levels and improve hemorheological indexes with good safety.
期刊: 2017年第28卷第29期
作者: 方翔,李侠,刘旭辉
AUTHORS: FANG Xiang,LI Xia,LIU Xuhui
关键字: 红花黄色素;老年患者;糖尿病肾病;急性心肌梗死;炎症因子;血液流变学;疗效;安全性
KEYWORDS: Safflower yellow pigment; Elderly patient; Diabetic nephropathy; Acute myocardial infraction; Inflammatory factor; Hemorheological; Therapeutic efficacy; Safety
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