益肾化湿颗粒联合氯沙坦钾片治疗慢性肾小球肾炎的临床观察
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篇名: 益肾化湿颗粒联合氯沙坦钾片治疗慢性肾小球肾炎的临床观察
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摘要: 目的:观察益肾化湿颗粒联合氯沙坦钾片对慢性肾小球肾炎(以下简称“慢性肾炎”)患者肾功能指标和炎症因子的影响。方法:选取2015年1月-2016年8月我院收治的慢性肾炎患者107例,按照治疗方案分为观察组(53例)和对照组(54例)。除进行基础治疗外,对照组患者给予氯沙坦钾片50 mg,po,qd;观察组患者在对照组基础上给予益肾化湿颗粒10 g,po,tid。两组患者均连续治疗2个月。观察两组患者的临床疗效、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白定量和尿红细胞]和炎症因子[白细胞介素13(IL-13)、C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)]水平,并记录不良反应发生情况。结果:观察组患者临床总有效率(86.79%)明显高于对照组(66.67%),差异有统计学意义(P<0.05)。治疗前,两组患者肾功能指标、炎症因子水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者肾功能指标、炎症因子水平均明显降低,且观察组明显低于对照组,差异均有统计学意义(P<0.05)。两组患者在治疗过程中均未见明显不良反应发生。结论:益肾化湿颗粒联合氯沙坦钾片治疗慢性肾炎,可改善患者肾功能,降低炎症因子水平,且安全性较高。
ABSTRACT: OBJECTIVE: To observe the effects of Yishen huashi granules combined with Losartan potassium tablets on renal function indexes and inflammatory factors of patients with chronic glomerulonephritis. METHODS: A total of 107 patients with chronic glomerulonephritis in our hospital during Jan. 2015-Aug. 2016 were divided into observation group (53 cases) and control group (54 cases) according to therapy plan. Besides basic therapy, control group was given Losartan potassium tablets 50 mg, po,qd; observation group was additionally given Yishen huashi granules 10 g, po,tid, on the basis of control group. Both groups were treated for consecutive 2 mouths. Clinical efficacies, renal function indexes (Scr, BUN, 24 h urine protein quantification, urine red blood cell) and inflammatory factors (IL-13, CRP, TNF-α) levels were all observed in 2 groups, and the occurrence of ADR was recorded. RESULTS: Clinical total response rate of observation group (86.79%) was significantly higher than that of control group (66.67%), with statistical significance (P<0.05). Before treatment, there was no statistical significance in renal function indexes or inflammatory factors levels between 2 groups (P>0.05). After treatment, renal function indexes and inflammatory factors levels of 2 groups were significantly decreased; and observation group was significantly lower than control group, with statistical significance (P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:  Yishen huashi granules combined with Losartan potassium tablets in the treatment of chronic glomerulonephritis can improve renal function and reduce inflammation factor level with good safety.
期刊: 2017年第28卷第29期
作者: 罗进辉,张慧
AUTHORS: LUO Jinhui,ZHANG Hui
关键字: 慢性肾小球肾炎;益肾化湿颗粒;氯沙坦钾片;肾功能;炎症因子
KEYWORDS: Chronic glomerulonephritis;Yishen huashi granules; Losartan potassium tablets; Renal function; Inflammatory factor
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